Clinical Observation of Fourteen-Needle Awakening Acupuncture Combined with Repetitive Transcranial Magnetic Stimulation in Treating Post-stroke Patients with Minimally Conscious State
10.13359/j.cnki.gzxbtcm.2025.10.009
- VernacularTitle:促醒十四针法联合重复经颅磁刺激治疗脑卒中后最小意识状态患者的临床观察
- Author:
Jianshuang SHI
1
;
Xi WEN
;
Xiaoyin WANG
;
Fangyi LU
;
Xiuwei CAI
Author Information
1. 广州中医药大学第五临床医学院,广东 广州 510095;广东省第二中医院,广东 广州 510095
- Keywords:
Fourteen-Needle Awakening Acupuncture;
repetitive transcranial magnetic stimulation(rTMS);
stroke;
minimally conscious state(MCS);
clinical observation
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(10):2422-2428
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effects of Fourteen-Needle Awakening Acupuncture combined with repetitive transcranial magnetic stimulation(rTMS)on post-stroke patients with minimally conscious state(MCS).Methods Sixty MCS patients admitted to the Rehabilitation Department of Guangdong Second Traditional Chinese Medicine Hospital between December 2023 and December 2024 were randomly divided into an observation group and a control group,with 30 cases in each group.Both groups received conventional awakening therapy.The control group received additional sham rTMS,while the observation group received Fourteen-Needle Awakening Acupuncture combined with rTMS.The treatment duration was 14 days for both groups.After two weeks,awakening status was evaluated.Changes in Coma Recovery Scale-Revised(CRS-R)scores,Glasgow Coma Scale(GCS)scores,Full Outline of Unresponsiveness(FOUR)scores,as well as serum levels of vascular endothelial growth factor(VEGF)and neuron-specific enolase(NSE)were compared between groups before and after treatment.Results(1)After treatment,17 patients in the observation group regained consciousness,with a recovery rate of 56.67％(17/30);9 patients in the control group regained consciousness,with a recovery rate of 30.00％(9/30).The recovery rate in the observation group was significantly higher than that in the control group(P＜0.05).(2)After treatment,the CRS-R scores in both groups were significantly improved(P＜0.05),with the observation group showing a greater degree of improvement(P＜0.05).(3)After treatment,the FOUR scores and GCS scores of both groups were significantly improved(P＜0.05),with the observation group showing a greater degree of improvement(P＜0.05).(4)After treatment,the serum VEGF and NSE levels of both groups were significantly improved(P＜0.05),with the observation group showing a greater degree of improvement(P＜0.05).Conclusion Fourteen-Needle Awakening Acupuncture combined with rTMS effectively enhances cortical excitability and modulates electrophysiological activity of cerebral neurons in post-stroke MCS patients.This combined therapy demonstrates positive therapeutic effects in improving MCS and significantly accelerates consciousness recovery.
