Clinical Efficacy of Huatuo Zaizao Pills Combined with Clopidogrel in Ischemic Cerebrovascular Disease Patients with Cognitive Dysfunction and Its Effects on Hcy,BNP,and S-100β Levels
10.13359/j.cnki.gzxbtcm.2025.10.008
- VernacularTitle:华佗再造丸联合氯吡格雷对缺血性脑血管病伴认知功能障碍患者的临床疗效及其对Hcy、BNP和S-100β水平的影响
- Author:
Guobin XIA
1
;
Ye ZHANG
;
Dongmei XING
Author Information
1. 云南省第三人民医院中医科,云南 昆明 650011
- Keywords:
Huatuo Zaizao Pills;
Clopidogrel;
ischemic cerebrovascular disease;
cognitive dysfunction;
coagulation function;
homocysteine;
brain natriuretic peptide;
S-100 calcium-binding protein β subunit(S-100β);
clinical efficacy
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(10):2414-2421
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of Huatuo Zaizao Pills combined with Clopidogrel in patients with ischemic cerebrovascular disease and cognitive dysfunction(phlegm-stasis obstructing the collaterals syndrome)and to observe their effects on homocysteine(Hcy),brain natriuretic peptide(BNP),and S-100β levels.Methods Ninety-five patients with ischemic cerebrovascular disease and cognitive dysfunction(phlegm-stasis obstructing the collaterals syndrome)treated at the Third People's Hospital of Yunnan Province from January 2022 to December 2024 were enrolled and randomized into a control group(n=48,treated with clopidogrel alone)and a study group(n=47,treated with clopidogrel plus Huatuo Zaizao Pills).Both groups received treatment for 3 months.Cognitive function was assessed using the Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA),and National Institutes of Health Stroke Scale(NIHSS)scores.Coagulation function was measured via fibrinogen(Fib),activated partial thromboplastin time(APTT),prothrombin time(PT),and thrombin time(TT).Serum Hcy,BNP,and S-100β levels were quantified by ELISA.Clinical efficacy and safety were evaluated after 3 months of treatment.Pearson correlation analysis was performed to assess relationships of Hcy,BNP and S-100β levels with cognitive function and coagulation parameters.Results(1)The total effective rate was significantly higher in the study group(91.49％,43/47)than that in the control group(72.92％,35/48)(P＜0.05,by chil-square test).(2)After treatment,both groups showed improved MMSE scores and MoCA scores(P＜0.01)and reduced NIHSS scores(P＜0.01),with greater improvements in the study group(P＜0.05).(3)Both groups exhibited improved Fib,APTT,PT,and TT(P＜0.05 or P＜0.01),with more pronounced enhancements in the study group(P＜0.05).(4)Hcy,BNP,and S-100β levels decreased in both groups(P＜0.05 or P＜0.01),with greater reductions in the study group(P＜0.05).(5)Pearson correlation analysis showed that the Hcy,BNP,and S-100β levels were negatively correlated with MMSE,MoCA,APTT,PT,and TT(P＜0.01)but were positively correlated with NIHSS and Fib(P＜0.01).(6)Adverse event rates were 10.42％(5/48)in the control group,17.02％(8/47)in the study group,with no stsatistically significance(P＞0.05).Conclusion The combination of Huatuo Zaizao Pills and Clopidogrel significantly improves cognitive function,coagulation parameters,and clinical outcomes in ischemic cerebrovascular disease patients with cognitive dysfunction(phlegm-stasis obstructing the collaterals syndrome),with a favorable safety profile.The mechanism may involve the downregulation of serum Hcy,BNP,and S-100β levels.
