Study on the Distribution Characteristics of TCM Syndrome Elements and Their Correlation with Influencing Factors in Asthma-COPD Overlap Based on Syndrome Element Differentiation
10.13359/j.cnki.gzxbtcm.2025.10.003
- VernacularTitle:基于证素辨证学探讨哮喘-慢阻肺重叠的中医证素分布特点及其影响因素的相关性研究
- Author:
Yunying YANG
1
;
Jingyi WU
;
Haifang ZHAO
Author Information
1. 广州中医药大学第五临床医学院,广东 广州 510405
- Keywords:
asthma-COPD overlap(ACO);
TCM syndrome elements;
retrospective study;
influencing factors;
correlation;
lung;
heart;
exterior;
deficiency in the origin and excess in the superficiality
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(10):2380-2386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the TCM syndrome characteristics,inherent patterns,and the relationships between TCM syndrome elements and related factors in patients with asthma-chronic obstructive pulmonary disease(COPD)overlap(ACO).Methods A retrospective analysis was conducted on the medical records of 72 ACO patients to determine the distribution of TCM syndrome elements and to analyze their correlations with underlying diseases and laboratory indicators.Results(1)Among the 72 ACO patients,the involved diseases-location syndrome elements included lung,heart,exterior,kidney,liver,small intestine,spleen,and meridians,while disease-nature syndrome elements included phlegm,yin deficiency,heat,qi deficiency,fluid retention,blood deficiency,dampness,yang deficiency,cold,blood stasis,external wind,qi stagnation,parasitic infestation,dryness,food stagnation,and instability.(2)The study identified 17 combinations of diseases-location syndrome elements,and the two-element combinations were the most common forms(40.28％,29/72),including"lung+exterior"(18.06％),"lung+heart"(16.67％),and"lung+heart+exterior"(9.72％).A total of 55 combinations of disease-nature syndrome elements were observed,with mixed deficiency-excess patterns(58.57％,41/70)being predominant.Common combinations included"phlegm+heat+yin deficiency"(5.71％),"phlegm+yin deficiency"(4.29％),"phlegm+heat"(4.29％),and"phlegm+heat+dampness+yin deficiency"(4.29％).(3)Logistic regression analysis revealed that in ACO patients,pulmonary hypertension was positively correlated with qi deficiency(OR=1.169,P＜0.05),serving as an independent risk factor for qi deficiency.Smoking was positively correlated with qi deficiency(OR=7.108,P＜0.05)and heart involvement(OR=29.189,P＜0.01),acting as their independent risk factors.Diabetes was positively correlated with exterior syndrome(OR=7.091,P＜0.05)and acted its independent risk factor,while hemoglobin levels were negatively correlated with exterior syndrome(OR=0.969,P＜0.05),acting as a protective factor.Conclusion ACO mainly involves the lung,with associations to the heart and exterior.Its nature is characterized by deficiency in the origin and excess in the superficiality,with yin deficiency and qi deficiency as predominant deficiencies and phlegm as the primary excess,often accompanied by heat,fluid retention,and dampness.Patients with pulmonary hypertension are more prone to qi deficiency,those with a smoking history exhibit higher risks of qi deficiency and heart involvement,diabetic patients are more likely to present exterior syndrome,and the increase of hemoglobin levels may reduce the occurrence of exterior syndrome.
