Exploring the Medication Rules and Therapeutic Mechanism of Traditional Chinese Medicine in Treating Laryngopharyngeal Reflux Disease Based on Data Mining and Network Pharmacology
10.13359/j.cnki.gzxbtcm.2025.09.025
- VernacularTitle:基于数据挖掘及网络药理学探讨中药治疗喉咽反流的用药规律及作用机制
- Author:
Weiming LIANG
1
;
Die WU
;
Guojing WU
;
Shiqing ZHOU
;
Wenyong CHEN
Author Information
1. 广州中医药大学第二临床医学院,广东 广州 510405
- Keywords:
laryngopharyngeal reflux disease;
Chinese medicine;
data mining;
network pharmacology;
tonifying herbs;
phlegm-resolving herbs;
Glycyrrhizae Radix et Rhizoma-Citri Reticulatae Pericarpium-Poria;
inflammatory response
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(9):2261-2270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prescription patterns and potential therapeutic mechanisms of traditional Chinese medicine(TCM)in treating laryngopharyngeal reflux disease(LPRD)based on data mining and network pharmacology.Methods The clinical data from 1 016 LPRD patients treated at the Guangdong Provincial Hospital of Chinese Medicine between February 1,2012,and December 30,2023 were collected.Frequency analysis,property and flavor analysis,meridian tropism analysis,efficacy classification,association rule mining,and cluster analysis were performed on the effective TCM prescriptions to identify medication rules.Core herbs were screened,and their therapeutic mechanisms were explored using network pharmacology.Results A total of 1 976 prescriptions involving 139 medicinals(23 644 medicinal frequencies)were analyzed.The top five most frequently-used medicinals were Glycyrrhizae Radix et Rhizoma(Gancao),Poria(Fuling),Citri Reticulatae Pericarpium(Chenpi),Bombyx Batryticatus(Jiangcan),and Galli Gigerii Endothelium Corneum(Jineijin).The herbs predominantly exhibited sweet flavor and neutral property,with a primary affinity for the lung meridian.The most common therapeutic categories were deficiency-tonifying herbs and phlegm-resolving herbs.The herb combination"Gancao-Chenpi-Fuling"was identified as the core prescription for LPRD.Network pharmacology analysis of this combination revealed 11 shared targets between the core herbs and LPRD,including three key targets.The core herbs may alleviate LPRD by modulating the interleukin-17(IL-17)signaling pathway,tumor necrosis factor(TNF)signaling pathway,and cancer-related pathways.Conclusion TCM treatment for LPRD should primarily target the lung,and employs herbs with mild-sweet properties and tonifying effects,supplemented by phlegm-resolving herbs.The core combination"Gancao-Chenpi-Fuling"may exert therapeutic effects by regulating key targets such as IL-1B,TNF,and IL-6,thereby modulating the IL-17 signaling pathway,TNF signaling pathway,and cancer-related pathways to mitigate inflammatory responses in LPRD.
