Clinical Observation of Jiannao Kaiqiao Acupuncture Combined with Sensory Integration Training in Children with Autism Spectrum Disorder
10.13359/j.cnki.gzxbtcm.2025.09.018
- VernacularTitle:健脑开窍针联合感觉统合训练治疗孤独症谱系障碍患儿的临床观察
- Author:
Sufen HU
1
;
Zhihai LYU
;
Lei XIAO
;
Yuehang LI
;
Qingwei ZENG
Author Information
1. 深圳市龙岗区妇幼保健院,广东 深圳 518172
- Keywords:
Jiannao Kaiqiao Acupuncture;
sensory integration training(SIT);
autism spectrum disorder(ASD);
cognitive function;
gut microbiota;
children;
clinical observation
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(9):2212-2217
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of Jiannao Kaiqiao Acupuncture combined with sensory integration training(SIT)in children with autism spectrum disorder(ASD)based on the brain-gut interaction theory.Methods A total of 135 children diagnosed with ASD at the Shenzhen Longgang Maternal and Child Health Hospital from March 2021 to March 2024 were enrolled.The patients were randomly divided into an observation group and a control group,with 68 patients in each group.The control group was given SIT treatment,while the observation group was treated with Jiannao Kaiqiao Acupuncture plus SIT,both groups were treated for 3 months.The changes in Childhood Autism Rating Scale(CARS)scores,Autism Behavior Checklist(ABC)scores,developmental quotient(DQ),serum neurofilament light chain(NFL),S100 calcium-binding protein β(S100β),and gut microbiota(Lactobacillus,Enterococcus,Bifidobacterium,Escherichia coli)were observed.Results(1)Both groups showed significant improvements in CARS,ABC,and DQ scores(P＜0.05),the observation group showed superior improvements compared to the control group,the difference being statistically significant(P＜0.05).(2)Serum NFL and S100β levels improved in both groups(P＜0.05),the observation group showed superior improvements compared to the control group,the difference being statistically significant(P＜0.05).(3)Gut microbiota composition(Lactobacillus,Enterococcus,Bifidobacterium,Escherichia coli)significantly normalized in both groups(P＜0.05),the observation group showed superior improvements compared to the control group,the difference being statistically significant(P＜0.05).(4)The total efficacy rate was 94.06％(66/68)in the observation group versus 85.07％(57/67)in the control group,the observation group showed superior improvements compared to the control group,the difference being statistically significant(P＜0.05).Conclusion Jiannao Kaiqiao Acupuncture combined with SIT effectively enhances cognitive function,alleviates clinical symptoms,modulates serum NFL/S100β levels,and restores gut microbiota balance in children with ASD.
