Therapeutic Effect of Liuwei Dihuang Wan Combined with Prednisone in Children with Nephrotic Syndrome and Its Effects on Immunoglobulin,Coagulation Function,and Renal Function
10.13359/j.cnki.gzxbtcm.2025.09.013
- VernacularTitle:六味地黄丸联合泼尼松治疗肾病综合征患儿疗效及对免疫球蛋白、凝血功能及肾功能的影响
- Author:
Yonghong CHEN
1
;
Ling LIANG
;
Yang LI
Author Information
1. 安徽中医药大学第一附属医院儿科,安徽 合肥 230031
- Keywords:
Liuwei Dihuang Wan;
prednisone;
nephrotic syndrome;
liver-kidney yin deficiency syndrome;
children;
immunoglobulin;
coagulation function;
renal function
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(9):2176-2182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Liuwei Dihuang Wan(LWDHW)combined with prednisone on immunoglobulin levels,coagulation function,and renal function in children with nephrotic syndrome(NS).Methods A total of 86 children diagnosed with NS and liver-kidney yin deficiency syndrome at the First Affiliated Hospital of Anhui University of Chinese Medicine from January 2019 to January 2024 were randomly divided into a control group and an observation group,with 43 cases in each group.Both groups of children received conventional symptomatic treatment,including a low-salt diet,diuresis,anticoagulation,and lipid-lowering therapy.In addition,the control group received standard treatment with prednisone,while the observation group received the same treatment as the control group plus LWDHW in decoction for 3 months.Traditional Chinese medicine(TCM)syndrome scores,immunoglobulins(IgA,IgG,IgM),coagulation parameters[fibrinogen(FBG),activated partial thromboplastin time(APTT),prothrombin time(PT)],and renal function markers[serum creatinine(Scr),blood urea nitrogen(BUN)]were observed before and after treatment.Clinical efficacy and adverse events were compared.Results(1)After 3 months of treatment,the overall response rate in the observation group was 95.35％(41/43),while that in the control group was 79.07％(34/43).The intergroup comparison(by chi-square test)revealed that the therapeutic efficacy of the observation group was significantly superior to that of the control group(P＜0.05).(2)After treatment,the TCM syndrome scores for soreness/weakness of waist/knees,dizziness/tinnitus,feverish sensation in the chest,palms and soles,and afternoon tidal fever in both groups of children were significantly lower than thsoe before treatment(P＜0.05).Additionally,the reduction in scores for all TCM syndromes in the observation group was significantly greater than that in the control group(P＜0.05 or P＜0.01).(3)After treatment,the IgA and IgG levels in both groups of children increased compared to before treatment(P＜0.05).There was a trend of increased IgM levels in both groups after treatment,but the differences were not statistically significant(P＞0.05);the post-treatment intergroup comparison showed that the increase in IgA and IgG levels in the observation group was significantly greater than that in the control group(P＜0.05 or P＜0.01).(4)After treatment,the PT levels of both groups of children were prolonged compared to before treatment(P＜0.05),the FBG levels were reduced compared to before treatment(P＜0.05),and the APTT levels showed no significant changes compared to before treatment(P＞0.05).After treatment,the improvement in PT and FBG levels in the observation group was significantly better than that in the control group(P＜0.01).(5)After treatment,the Scr and BUN levels in both groups decreased compared to before treatment(P＜0.05),and the reduction in Scr and BUN levels in the observation group was significantly greater than that in the control group(P＜0.01).(6)In terms of adverse reactions,the incidence rates in the observation group and control group were 6.97％(3/43)and 2.32％(1/43),respectively.There was no statistically significant difference between the two groups(x2=1.049,P＞0.05).Conclusion LWDHW combined with prednisone effectively improves clinical efficacy,alleviates TCM syndromes,modulates immune function,reduces hypercoagulability,and enhances renal function in children with NS and liver-kidney yin deficiency,with good safety.
