Clinical Observation of Zhuanggu Kangsong Soft Extract Combined with Percutaneous Vertebroplasty in the Treatment of Osteoporotic Vertebral Compression Fractures
10.13359/j.cnki.gzxbtcm.2025.09.012
- VernacularTitle:壮骨抗松膏联合经皮椎体成形术治疗骨质疏松性椎体压缩骨折疗效观察
- Author:
Jiaming CAO
1
;
Wang TANG
;
Yonghui FENG
;
Donghua LIU
Author Information
1. 广州中医药大学,广东 广州 510405
- Keywords:
Zhuanggu Kangsong Soft Extract;
percutaneous vertebroplasty;
osteoporotic vertebral compression fracture;
clinical efficacy;
bone metabolism;
bone mineral density
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(9):2170-2175
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of Zhuanggu Kangsong Soft Extract combined with percutaneous vertebroplasty(PVP)in the treatment of osteoporotic vertebral compression fractures(OVCF).Methods A total of 90 eligible OVCF patients admitted to Guangzhou Integrated Chinese and Western Medicine Hospital between January 2023 and May 2024 were enrolled and randomly divided into an observation group(n=45)and a control group(n=45)using a random number table.Both groups underwent PVP.After treatment,the control group received conventional western medication orally(calcium carbonate D3 tablets+calcitriol soft capsules),while the observation group received additional Zhuanggu Kangsong Soft Extract treatment orally.Western medication was administered for 6 months,and herbal treatment lasted 3 months.Changes in Visual Analogue Scale(VAS)scores for pain,Oswestry Disability Index(ODI)scores for low back function,bone mineral density(BMD)T-values,and serum bone metabolism markers were observed before and after treatment.Results(1)At postoperative day 3,3 months,and 6 months,both groups showed significant improvements in VAS and ODI scores compared to those before treatment(P＜0.05).The observation group demonstrated superior improvements in VAS and ODI scores at 3 and 6 months compared to the control group(P＜0.05).(2)At 3,6,and 12 months postoperatively,BMD T-values were improved in both groups(P＜0.05),with the observation group exhibiting greater improvements at 6 and 12 months(P＜0.05).(3)Serum N-terminal osteocalcin and 25-hydroxyvitamin D3[25(OH)D3]levels increased in both groups at 1,3,and 6 months(P＜0.05).The observation group showed more pronounced elevations in these markers at 3 and 6 months(P＜0.05).Conclusion The combination of Zhuanggu Kangsong Soft Extract and PVP demonstrates significant therapeutic benefits for OVCF by effectively alleviating pain,enhancing BMD,and improving activities of daily living,which highlights its high clinical value.
