Analysis of TCM Syndrome Distribution and Clinical Efficacy of Jianpi Yishen Paidu Therapy in Maintenance Hemodialysis Patients
10.13359/j.cnki.gzxbtcm.2025.09.003
- VernacularTitle:维持性血液透析患者证型分布及健脾益肾排毒法临床疗效分析
- Author:
Yi OUYANG
1
;
Jiahao XIE
;
Shuai WANG
Author Information
1. 广州中医药大学,广东 广州 510006;广州市中西医结合医院,广东 广州 510800
- Keywords:
end-stage renal disease;
maintenance hemodialysis(MHD);
TCM syndromes;
spleen-kidney qi deficiency syndrome;
spleen-kidney yang deficiency syndrome;
dampness-turbidity syndrome;
blood stasis syndrome;
Jianpi Yishen Paidu Therapy;
renal function;
calcium-phosp
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(9):2105-2113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the distribution of traditional Chinese medicine(TCM)syndromes in maintenance hemodialysis(MHD)patients and to evaluate the clinical efficacy of Jianpi Yishen Paidu Therapy(mainly with the actions of strengthening spleen,tonifying kidney,and removing toxins)across different syndrome types.Methods A total of 173 patients with stage 5 chronic kidney disease(CKD)undergoing MHD at Guangzhou Hospital of Integrated Traditional and Western Medicine between October 2019 and October 2024 were enrolled.Statistical analysis was performed on TCM syndrome distribution.Patients were categorized into three groups based on whether they received Jianpi Yishen Paidu Therapy for 2 weeks and their syndrome differentiation:spleen-kidney qi deficiency syndrome group(n=25),spleen-kidney yang deficiency syndrome group(n=39),and control group(n=109).Baseline data and laboratory parameters were collected to assess therapeutic efficacy of Jianpi Yishen Paidu Therapy.Results(1)Among deficiency patterns,spleen-kidney qi deficiency and spleen-kidney yang deficiency syndromes predominated;among excess syndromes,dampness-turbidity and blood stasis syndromes were most common.(2)Adjunctive Jianpi Yishen Paidu therapy enhanced treatment efficacy by decreasing serum creatinine(Scr),blood urea nitrogen(BUN),and cystatin C(Cys-C)levels while increasing hemoglobin(Hb)and serum albumin(ALB)(P＜0.05).Regarding calcium-phosphorus metabolism,the spleen-kidney qi deficiency group showed reduced serum phosphorus(P+)(P＜0.05),while both treatment groups(spleen-kidney qi/yang deficiency)exhibited elevated serum calcium(Ca2+)(P＜0.05)but with no intergroup difference in parathyroid hormone(PTH)(P＞0.05).No significant differences were observed in lipid profiles[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]among the three groups(P＞0.05).Dialysis vintage was significantly shortened in both treatment groups versus controls(P＜0.05).Conclusion MHD patients primarily exhibit spleen-kidney qi/yang deficiency syndromes(deficiency in the origin syndrome)and dampness-turbidity/blood stasis syndromes(excess in the superficiality syndrome).Syndrome differentiation-based intervention with Jianpi Yishen Paidu Therapy effectively delays renal function decline,improves calcium-phosphorus metabolism,and elevates Hb and ALB levels in MHD patients.
