Study on the Correlation Between Insulin Resistance Markers,Inflammatory Indicators,and Traditional Chinese Medicine Syndromes in Diabetic Kidney Disease Complicated by Carotid Atherosclerosis
10.13359/j.cnki.gzxbtcm.2025.09.002
- VernacularTitle:胰岛素抵抗指标及炎症指标与糖尿病肾脏疾病合并颈动脉粥样硬化中医证型之间的关联性研究
- Author:
Xiaochen LIN
1
;
Qi ZHANG
;
Xuefeng LI
;
Zhili CUI
Author Information
1. 浙江省温岭市中医院,浙江温岭 317500
- Keywords:
insulin resistance;
triglyceride-glucose(TyG)index;
inflammatory markers;
neutrophil-to-lymphocyte ratio;
C-reactive protein;
diabetic kidney disease;
carotid atherosclerosis;
TCM syndromes;
qi and yin deficiency syndrome
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(9):2097-2104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between insulin resistance markers[triglyceride-glucose(TyG)index],inflammatory indicators[neutrophil-to-lymphocyte ratio(NLR),C-reactive protein(CRP)],and traditional Chinese medicine(TCM)syndromes in patients with diabetic kidney disease(DKD)complicated by carotid atherosclerosis(CAS).Methods This retrospective study enrolled 300 DKD patients with CAS(case group)and 30 DKD patients without CAS(control group).Differences in TyG index,NLR,and CRP levels were compared between groups.The relationships between these markers and carotid intima-media thickness(IMT)/plaque area were analyzed,along with their variations across TCM syndromes.Logistic regression and receiver operating characteristic(ROC)curve analyses were performed to evaluate the predictive value of TyG index,NLR,and CRP for plaque stability and prognosis.Results(1)The TyG index,NLR,and CRP levels in patients with DKD and CAS were significantly higher than those in patients with DKD alone(P＜0.01).(2)The TyG index,NLR,and CRP were significantly positively correlated with IMT and plaque area(P＜0.01).(3)In patients with DKD combined with CAS,the TyG index,NLR,and CRP levels in those with unstable plaques were significantly higher than those with stable plaques(P＜0.01).(4)Among the distribution of TCM syndromes in patients with DKD combined with CAS,the qi and yin deficiency syndrome had the highest proportion(33.33％),followed by spleen and kidney yang deficiency syndrome(28.67％),yin and yang deficiency syndrome(22.00％),and turbid toxin and stasis obstruction syndrome(16.00％).(5)Among patients with DKD and CAS,the TyG index,NLR,and CRP levels in patients with different TCM syndromes decreased in the following order:turbid toxin and stasis obstruction syndrome,yin and yang deficiency syndrome,spleen-kidney yang deficiency syndrome,and qi and yin deficiency syndrome.(6)Logistic regression analysis results showed that TyG index,NLR,and CRP levels were closely associated with plaque stability in patients with DKD combined with CAS(P＜0.05 or P＜0.01).(7)ROC analysis showed that these markers have high prognostic value in DKD-CAS(P＜0.01).Conclusion TyG index,NLR,and CRP may serve as potential biomarkers for TCM syndrome differentiation and prognosis assessment in DKD-CAS.
