Research Progress on the Mechanism of Berberine in Preventing and Treating Sepsis Through Modulating Intestinal Mucosal Immune Barrier Function
10.13359/j.cnki.gzxbtcm.2025.08.037
- VernacularTitle:小檗碱调节肠黏膜免疫屏障功能以防治脓毒症的机制研究进展
- Author:
Zelin LI
1
;
Jinlan JIN
Author Information
1. 广州中医药大学深圳医院(福田)重症医学科,广东 深圳 518034
- Keywords:
berberine;
berberine hydrochloride;
sepsis;
intestinal mucosal immune barrier;
immune dysfunction;
Notch signaling;
review
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(8):2076-2082
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a systemic inflammatory response syndrome triggered by infection,and the abnormal inflammatory response leads to the damage of intestinal mucosal barrier.The intestinal mucosal barrier consists of four parts,namely biological barrier,chemical barrier,mechanical barrier,and immune barrier.The injured intestinal mucosal barrier is considered as the"initiating organ"of multiple organ dysfunctions in sepsis,with the immune barrier being particularly critical to the progression of sepsis.Berberine(also known as berberine hydrochloride)is an active alkaloid extracted from Berberaceae plants such as Coptidis Rhizoma,and possesses multiple pharmacological actions including antibacterial and anti-inflammatory effects.It has been widely used in the treatment of various diseases,including diarrhea and arrhythmias.This article reviewed the progress in recent research on the protective effects and mechanism of Berberine against sepsis-induced intestinal mucosal immune barrier damage.The recent studies have shown that berberine can modulate intestinal mucosal immune function in sepsis via regulating the TLRs signaling pathway,Notch signaling pathway,and dendritic cell(DC)function,by inducing ferroptosis of macrophages in intestinal mucosa,and by regulating the imbalance of gut microbiota in sepsis patients.The unique advantages of berberine and its promising application prospects in the treatment of sepsis have been demonstrated by its effects on protecting and repairing the intestinal mucosal barrier and on improving the sepsis-induced intestinal mucosal barrier damage.The in-depth research into its therapeutic mechanisms and the exploration of optimized strategies for using berberine to prevent and treat sepsis-induced intestinal mucosal barrier damage are of great significance for enhancing clinical outcomes in sepsis treatment,and will provide new insights and directions for the prevention and treatment of sepsis.
