Study on Correlation of Circuit-Qi Endowment During Embryonic with Susceptibility of Congenital Heart Disease
10.13359/j.cnki.gzxbtcm.2025.08.006
- VernacularTitle:胚胎发育期运气禀赋与先天性心脏病易患性研究
- Author:
Yingxie CAO
1
;
Jingping SUN
;
Yihua LI
;
Liang KANG
;
Qingmin CHU
;
Xinjun ZHAO
;
Rong LI
Author Information
1. 广州中医药大学第一临床医学院,广东 广州 510405
- Keywords:
congenital heart disease;
early embryogenesis;
at conception;
five circuits and six qi;
prevalence of disease;
etiology and pathogenesis;
heart-spleen insufficiency;
hyperactive heart-fire and cold kidney-water;
spleen deficiency failing in transportation
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(8):1869-1876
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the circuit-qi patterns during early embryonic period and at conception in congenital heart disease(CHD)patients based on the five-circuit and six-qi theory,and to explore the pathogenesis and etiology of CHD from a circuit-qi perspective.Methods With 16 400 non-CHD individuals as the healthy control group,a statistical analysis was performed for the circuit-qi patterns during early embryogenesis and at conception in 4 100 CHD patients(CHD group).Results The following factors were identified as significant predisposing factors for CHD:yearly circuit being excessive fire circuit during early embryogenesis,yearly qi being taiyang cold water of celestial qi combined with taiyin damp earth of terrestrial qi during early embryogenesis,yearly circuit being concurrent excessive fire circuit and earth circuit deficiency at conception,and yearly qi being taiyin damp earth of terrestrial qi paired with jueyin wind wood of celestial qi at conception(all P＜0.05 or P＜0.01).Conclusion There is a certain correlation between circuit-qi endowment during embryonic development and the prevalence of CHD.The core pathogenesis of CHD is rooted in heart-spleen insufficiency,with hyperactive heart-fire and cold kidney-water as its manifestations,and spleen deficiency failing in transportation serves as an important contributing factor in the development and progression of CHD.
