Characteristic Distribution of Traditional Chinese Medicine Syndrome Types in Gouty Arthritis Complicated with Bone Erosion and Analysis of the Associated Factors
10.13359/j.cnki.gzxbtcm.2025.08.005
- VernacularTitle:痛风性关节炎骨侵蚀中医证型分布特点及相关性分析
- Author:
Haiyan WANG
1
;
Xinru HU
;
Lingying XU
;
Baolin ZHENG
Author Information
1. 广州中医药大学第八临床医学院,广东 佛山 528000
- Keywords:
gouty arthritis;
bone erosion;
traditional Chinese medicine(TCM)syndrome type;
stagnant-heat obstruction syndrome;
phlegm-turbidity obstruction syndrome;
correlation
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(8):1864-1869
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristic distribution of traditional Chinese medicine(TCM)syndrome types in gouty arthritis patients complicated with bone erosion,and to analyze the associated factors.Methods A total of 318 gouty arthritis patients hospitalized in the Rheumatology and Immunology Department of Foshan Hospital of Traditional Chinese Medicine between November 2021 and November 2023 were included.The patients were allocated to a bone erosion group(142 cases)and a non-bone erosion group(176 cases)according to the findings of musculoskeletal ultrasound.The clinical data of gender,age,body height,body mass,body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),course of gout,findings of musculoskeletal ultrasound,complete blood count[white blood cell count(WBC),platelet count(PLT),hemoglobin(Hb),and red blood cell count(RBC)],blood uric acid(UA),creatinine(Cr),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C)of the patients during hospitalization were collected.Differences in general information,laboratory parameters,and distribution of TCM syndrome types were compared between the two groups,and then the potential influencing factors of bone erosion in gouty arthritis patients were explored.Results(1)Analysis of general information showed that the bone erosion group had longer course of gout and slightly lower BMI than that the non-bone erosion group,and the differences were statistically significant(P＜0.05 or P＜0.01).However,there were no statistically significant differences in age,body height,body mass,SBP and DBP among the patients of the two groups(P>0.05).(2)Analysis of laboratory indicators showed that the levels of Cr,UA,ESR and TC in the bone erosion group were significantly higher than those in the non-bone erosion group,and the differences were statistically significant(P＜0.05 or P＜0.01).However,no statistically significant differences in the levels of CRP,WBC,RBC,PLT and LDL-C were presented between the two groups(P＞0.05).(3)Analysis of the distribution of TCM syndromes showed that in the bone erosion group,stagnant-heat obstruction syndrome accounted for the largest proportion(33.10%),followed by phlegm-turbidity obstruction syndrome(29.58%),damp-heat accumulation syndrome(22.54%),and liver-kidney yin deficiency syndrome(14.79%);in the non-bone erosion group,damp-heat accumulation syndrome accounted for the largest proportion(38.07%),followed by liver-kidney yin deficiency syndrome(32.95%),phlegm-turbidity obstruction(14.77%),and stagnant-heat obstruction(14.20%).There was statistically significant difference in the distribution of TCM syndromes between the two groups(P＜0.01).(4)The results of logistic regression analysis suggested that the higher the levels of ESR,UA,and TC,the longer the course of gout.And the TCM syndromes of stagnant-heat obstruction and phlegm-heat obstruction were the risk factors for bone erosion in gouty arthritis(P＜0.05 or P＜0.01).Conclusion Gouty arthritis patients with bone erosion exhibit higher UA,ESR,Cr,and TC levels,longer course of disease,and higher incidence of stagnant-heat obstruction syndrome and phlegm-turbidity obstruction syndrome.Bone erosion in gouty arthritis is closely associated with elevated UA,ESR,TC,and some specific TCM syndrome patterns.
