Safety Analysis of Microwave Ablation for Colorectal Cancer Liver Metastases Integrating Traditional Chinese Medicine Syndrome Types and Development of A Multidimensional Prognostic Prediction Model
10.13359/j.cnki.gzxbtcm.2025.08.002
- VernacularTitle:融合中医证候的结直肠癌肝转移微波消融术安全性分析及预后多维预测模型构建
- Author:
Yunqi CHEN
1
;
Haiqi WU
;
Jiaming WU
;
Jincheng MENG
;
Cantu FANG
;
Huatang ZHANG
Author Information
1. 广州中医药大学附属中山中医院/中山市中医院肿瘤科,广东 中山 528400
- Keywords:
colorectal cancer liver metastases;
Traditional Chinese mendicine syndrome type;
qi-blood deficiency syndrome;
spleen-kidney yang deficiency syndrome;
microwave ablation;
multidimensional prediction model;
prognosis
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(8):1838-1848
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the impact of traditional Chinese medicine(TCM)syndromes on percutaneous microwave ablation(MWA)treatment in patients with colorectal cancer liver metastases(CRLM)and to construct a multidimensional prediction model prognostic based on TCM syndrome classification.Methods Clinical data were collected from 86 CRLM patients who underwent MWA at Zhongshan Hospital of Traditional Chinese Medicine between October 2012 and October 2023.The clinical information covered TCM syndrome types of qi-blood deficiency and spleen-kidney yang deficiency,tumor characteristics,and treatment parameters.Logistic regression was used to screen feature variables for constructing the prognostic predication model,and cross validation was performed to evaluate the prognostic predictive performance.Results(1)Among the 86 CRLM patients,31(36.05%)had spleen-kidney yang deficiency syndrome,while 55(63.95%)had qi-blood deficiency syndrome.(2)Compared to the patients with spleen-kidney yang deficiency syndrome,patients with qi-blood deficiency syndrome exhibited significantly long progression-free survival(PFS)and high progression-free survival rate(P＜0.01),while no significant differences were presented in the incidences of postoperative adverse events such as pain,fever,infection,liver function impairment,or ascites/pleural effusion among the patients with the two syndrome types(P＞0.05).(3)Multivariate logistic regression analysis revealed that TCM syndrome type,maximum diameter of metastatic liver tumor,timing of liver metastasis,and Ki-67 expression rate of primary tumors were the independent prognostic factors for 1-year PFS(P＜0.05 or P＜0.01).(4)The constructed model demonstrated high predictive accuracy for PFS,with an area under the receiver operating characteristic(ROC)curve(AUC)of 0.905(95%CI:0.830-0.980).Conclusion TCM syndromes have significant influence on the prognosis of CRLM patients undergoing MWA,and the patients with qi-blood deficiency syndrome have favorable prognosis.This study pioneers a multidimensional prognostic prediction model integrating TCM syndromes for MWA-treated CRLM patients,highlighting the unique value of TCM syndromes in assessing disease progression and predicting prognosis.
