Study on the Role of Nrf2/SLC7A11/GPX4 Signaling Pathway in the Pathogenesis of Ischemic Stroke and Research Progress on Traditional Chinese Medicine Intervention Based on Ferroptosis
10.13359/j.cnki.gzxbtcm.2025.07.039
- VernacularTitle:基于铁死亡探讨Nrf2/SLC7A11/GPX4信号通路在缺血性脑卒中发病中的作用及中医药干预研究进展
- Author:
Dacheng WEI
1
;
Linglu DUN
;
Changjun LU
;
Hongwei AN
;
Man WANG
;
Qichao YE
;
Hanchi LIANG
Author Information
1. 柳州市中医医院,广西 柳州 545002
- Keywords:
ischemic stroke;
ferroptosis;
Nrf2/SLC7A11/GPX4 signaling pathway;
traditional Chinese medicine;
acupuncture and moxibustion
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(7):1825-1830
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is a disease resulting from the cerebral ischemia and hypoxia caused by the blockage of brain vessels in the brain,and is characterized by the focal neurological signs.Pathologically,neuronal necrosis in the infarcted area and the neuronal degeneration or delayed death of neurons in the ischemic penumbra,contribute to the morphological basis of the disease.Ischemic stroke is regulated by multiple processes,including ferroptosis,apoptosis,and autophagy.Ferroptosis,a type of iron-dependent cell death,is closely associated with ischemic stroke.Nuclear factor erythroid 2-related factor 2(Nrf2),a key transcription factor,plays a critical role in maintaining cellular redox balance and regulating inflammatory responses.Nrf2 promotes the expression of solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4),thereby activating the Nrf2 signaling pathway to counteract ferroptosis and protect cells from damage.This article reviews and analyzes recent experimental studies on traditional Chinese medicine(TCM)therapy targeting the Nrf2/SLC7A11/GPX4 pathway to suppress ferroptosis.The studies have found that TCM therapy with herbal compounds,Chinese patent medicines,single herbal components and their active ingredients,and acupuncture and moxibustion can inhibit ferroptosis by activating the Nrf2/SLC7A11/GPX4 signaling pathway,which will provide novel strategies for the TCM intervention of ischemic stroke.
