Clinical Efficacy of Jianpi Qushi Method Combined with Chinese Herbal Fumigation Therapy in Treating Seborrheic Alopecia of Spleen Deficiency with Dampness-Accumulation Type and Its Impact on Hormone Levels
10.13359/j.cnki.gzxbtcm.2025.07.017
- VernacularTitle:健脾祛湿法联合中药熏蒸疗法治疗脾虚湿蕴型脂溢性脱发的疗效及对激素水平的影响
- Author:
Yi XIONG
1
;
Xiang HE
;
Dongming WANG
;
Lanxin GENG
Author Information
1. 上海中医药大学附属曙光医院皮肤科,上海 201203
- Keywords:
seborrheic alopecia;
Jianpi Qushi Method;
Chinese herbal fumigation therapy;
spleen deficiency with dampness-accumulation type;
clinical efficacy
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(7):1673-1680
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of Jianpi Qushi Method(a spleen-invigorating and dampness-removing approach)combined with Chinese herbal fumigation therapy in treating seborrheic alopecia of spleen deficiency with dampness-accumulation type and to observe its influence on hormone levels.Methods The observation was carried out in 104 patients with spleen deficiency with dampness-accumulation type of seborrheic alopecia,who admitted to the Department of Dermatology at Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2023 to February 2024.The patients were equally randomized into a trial group and a control group,with 52 cases in each group.The control group received oral administration of Finasteride Tablets,while the trial group was additionally treated with Jianpi Qushi Method combined with Chinese herbal fumigation therapy for 3 months.Serum hormone levels,hair loss scores,clinical symptom scores(including greasy hair,pruritus,scaling,and growth of new hair),and trichoscopic parameters of the hair in the two groups were assessed before and after treatment.After treatment,the clinical efficacy and adverse reactions in the two groups were also evaluated.Results(1)After 3 months of treatment,the total effective rate in the trial group was 94.23％(49/52)and that in the control group was 73.08％(38/52).The trial group demonstrated significantly superior efficacy compared to the control group(tested by chi-square test,P<0.01).(2)After treatment,both groups exhibited a significant decrease in serum testosterone level(P<0.05)and a significant increase in serum estradiol level(P<0.05)compared to those before treatment.Notably,the trial group showed a more pronounced reduction in testosterone and a greater elevation in estradiol than the control group(P<0.01).(3)Both groups displayed a significant reduction in hair loss scores after treatment(P<0.05),and the trial group achieved a markedly greater decrease than the control group(P<0.01).(4)After treatment,the clinical symptom scores for greasy hair,pruritus,scaling,and growth of new hair significantly decreased in both groups compared to those before treatment(P<0.05).And the trial group exhibited significantly greater improvements in the scores of all symptoms than the control group(P<0.01).(5)After treatment,both groups showed a significant increase in hair density(hairs/cm2)and count of upright regrowing hair(P<0.05),along with a significant decrease in vellus hair count,hair count in the single hair follicle,and count of perifollicular keratosis(P<0.05).The trial group demonstrated significantly superior improvements in all trichoscopic parameters compared to the control group(P<0.01).(6)No significant adverse reactions were observed in either group during the treatment period,indicating a favorable safety profile for both therapeutic approaches.Conclusion Jianpi Qushi Method combined with Chinese herbal fumigation therapy exerts significant efficacy in treating seborrheic alopecia of spleen deficiency with dampness-accumulation type.The combined therapy is effective on regulating hormone levels,promoting hair regeneration,and alleviating symptoms such as greasy hair and pruritus,and demonstrates favorable safety.
