Therapeutic Efficacy of Zhuyun Yangmo Formula Combined with Letrozole in Patients with Infertility Caused by Follicular Maldevelopment of Kidney Deficiency and Blood Stasis Syndrome Type
10.13359/j.cnki.gzxbtcm.2025.07.014
- VernacularTitle:助孕养膜方联合来曲唑对肾虚血瘀型卵泡发育不良不孕症的疗效观察
- Author:
Ziwei FANG
1
;
Yantong CEN
;
Feng GU
Author Information
1. 广州中医药大学,广东 广州 510006
- Keywords:
follicular maldevelopment;
infertility;
kidney deficiency and blood stasis syndrome type;
Zhuyun Yangmo Formula;
Letrozole;
pregnancy rate;
clinical efficacy
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(7):1652-1657
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of Zhuyun Yangmo Formula(composed of Dioscoreae Rhizoma,Corni Fructus,Cinnamomi Cortex,Cuscutae Semen,Chuanxiong Rhizoma,Angelicae Sinensis Radix,Lycii Fructus,Rehmanniae Radix Praeparata,Polygonati Rhizoma,Asini Corii Colla,Rubi Fructus,etc.)combined with Letrozole for the treatment of patients with infertility caused by follicular maldevelopment(FM)of kidney deficiency and blood stasis syndrome type.Methods Sixty patients with FM-caused infertility of kidney deficiency and blood stasis syndrome type treated at the Reproductive Medicine Department of Qingyuan Hospital of Traditional Chinese Medicine from February 2024 to August 2024 were randomized into a control group(30 cases,treated with Letrozole alone)and an observation group(30 cases,treated with Zhuyun Yangmo Formula plus Letrozole)for three menstrual cycles.Primary outcomes of maximum diameter of preovulatory follicles and serum levels of estradiol(E2),luteinizing hormone(LH),and follicle-stimulating hormone(FSH)in the two groups were observed before and after treatment.After treatment,the pregnancy rates in the two groups were compared.Results After treatment,serum E2,LH and FSH levels in both groups were significantly increased compared to those before treatment(P＜0.05),and the observation group showed significantly greater increase than the control group,with statistically significant differences(P＜0.01).(2)After treatment,both groups showed improvement in the maximum diameter of preovulatory follicles compared to that before treatment(P＜0.05),and the observation group demonstrated significantly better improvement than the control group,with a statistically significant difference(P＜0.01).(3)After 3 menstrual cycles of treatment,the pregnancy rate in the observation group was 40.00%(12/30),significantly higher than 16.67%(5/30)in the control group,with a statistically significant difference(P＜0.05).Conclusion Zhuyun Yangmo Formula combined with Letrozole demonstrates superior efficacy in improving follicular development,elevating serum E2,LH and FSH levels,and increasing pregnancy rates in patients with FM-caused infertility of kidney deficiency and blood stasis syndrome type when compared to Letrozole monotherapy alone.
