Effects of Modified Simiao San Combined with Metronidazole on Immune Factors,Inflammatory Factors and Oxidative Stress in Patients with Bacterial Vaginosis
10.13359/j.cnki.gzxbtcm.2025.07.013
- VernacularTitle:四妙散加减方联合甲硝唑治疗对细菌性阴道炎患者免疫炎症因子及氧化应激的影响
- Author:
Junxia ZHU
1
;
Chunjing ZHAO
;
Xishuang GONG
;
Naiping WANG
Author Information
1. 广州中医药大学东莞医院,广东 东莞 523000
- Keywords:
bacterial vaginosis;
modified Simiao San;
Metronidazole Tablets;
immune factors;
inflammatory factors;
oxidative stress
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(7):1645-1651
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of modified Simiao San combined with Metronidazole Tablets on immune factors,inflammatory factors,and oxidative stress in patients with bacterial vaginosis(BV).Methods Eighty BV patients treated at Dongguan Hospital of Guangzhou University of Chinese Medicine(Dongguan Traditional Chinese Medicine Hospital)from March 2023 to April 2024 were equally randomly divided into a control group(40 cases,treated with Metronidazole Tablets)and a study group(40 cases,treated with modified Simiao San plus Metronidazole Tablets).The treatment for the two groups lasted for 7 days.Serum immunologic factors[immunoglobulin(Ig)A,IgG,and IgM],inflammatory factors[C-reactive protein(CRP),tumor necrosis factor α(TNF-α),and interleukin-6(IL-6)],and oxidative stress markers[superoxide dismutase(SOD),malondialdehyde(MDA),and glutathione peroxidase(GSH-Px)]in the two groups were measured before and after treatment.After treatment,symptom resolution time,clinical efficacy,and the incidence of total adverse reactions were compared between the two groups.Results(1)After 7 days,the total effective rate was 95.00%(38/40)in the study group versus 77.50%(31/40)in the control group(tested by chi-square test,P＜0.05).(2)The study group showed significantly shorter time to the resolution of profuse or scanty leukorrhea,odor of leukorrhea,vulvar itching,vaginal pain,and vaginal mucosal hyperemia(all P＜0.01)than the control group.(3)After treatment,both groups exhibited increased IgA,IgG,and IgM(P＜0.05)compared to those before treatment,with greater improvements in the study group(P＜0.01).(4)After treatment,serum levels of inflammatory factors of CRP,TNF-α,and IL-6 in both groups decreased(P＜0.05),with superior reductions in the study group(P＜0.01).(5)After treatment,serum levels of oxidative stress markers of SOD and GSH-Px levels rose(P＜0.05),while MDA declined(P＜0.05)in both groups,and the study group demonstrated more pronounced improvements(P＜0.01).(6)Adverse reaction rates were 5.00%(2/40)and 15.00%(6/40)in the study group and control group,respectively,the differentce being no statistical significance between the two groups(P＞0.05).Conclusion Modified Simiao San combined with Metronidazole Tablets significantly alleviates BV symptoms,improves immune function,and inhibits inflammatory response and oxidative stress,demonstrating satisfactory efficacy and high safety.
