Study on the Distribution of Traditional Chinese Medicine Syndromes in Invasive Pulmonary Aspergillosis Based on Factor Analysis and Cluster Analysis
10.13359/j.cnki.gzxbtcm.2025.07.002
- VernacularTitle:基于因子分析及聚类分析的侵袭性肺曲霉病中医证候分布规律
- Author:
Yanxiao XIE
1
;
Dong SONG
;
Lin XIE
;
Ziyun JIANG
;
Leshen LIAN
;
Xusheng QIAN
Author Information
1. 广州中医药大学东莞医院,广东 东莞 523000;广州中医药大学研究生院,广东 广州 510006;东莞市分子医学检验重点实验室,广州中医药大学东莞医院,广东 东莞 523127
- Keywords:
invasive pulmonary aspergillosis;
syndrome patterns;
factor analysis;
cluster analysis;
phlegm-heat congesting the lung syndrome;
clearing heat and resolving phlegm
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(7):1561-1568
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics and distribution patterns of traditional Chinese medicine(TCM)syndromes in invasive pulmonary aspergillosis(IPA).Methods A retrospective analysis was conducted on 232 IPA patients who were admitted at Dongguan Hospital of Guangzhou University of Chinese Medicine between August 2019 and August 2024.General clinical data and TCM symptom information were collected to establish a database of TCM syndrome for IPA.Factor analysis and cluster analysis were performed,and the results were interpreted by combining with clinical practice to investigate the distribution patterns of TCM syndromes.Results Among 232 IPA patients,42 TCM syndrome factors were identified after excluding the syndrome factors with the frequency below 5%.The common TCM symptoms of IPA were frequent cough,wheezing,dry cough without sputum or with scant sputum,thick or purulent sputum,and chest tightness and distress,all having the frequency above 65%.Integrated factor analysis and cluster analyse revealed five major TCM syndrome patterns:phlegm-heat congesting the lung syndrome(29.74%),phlegm-damp accumulating in the lung syndrome(20.26%),qi-yin deficiency syndrome(23.28%),lung-kidney qi deficiency syndrome(15.09%),and deficient-fire scorching the lung syndrome(11.64%).The fundamental pathogenesis of IPA was characterized by deficiency in the origin and excess in the superficiality,and deficiency interweaved with excess.IPA primarily involved the lung,with secondary involvement of the spleen and kidney.Conclusion Phlegm-heat congesting the lung syndrome is the most common TCM syndrome pattern in IPA patients,reflecting a complexity of deficiency in the origin and excess in the superficiality,and deficiency interweaved with excess.Treatment of IPA should prioritize clearing heat and resolving phlegm,while adjunctive strategies such as drying dampness and resolving phlegm,tonifying qi and nourishing yin,supplementing lung and kidney,or nourishing yin to purge fire,should be tailored to specific syndrome manifestations.
