Exploration on the Clinical Experience of Wang Yan'gang in Treating Gastroesophageal Reflux Disease Based on Data Mining
10.13359/j.cnki.gzxbtcm.2025.06.030
- VernacularTitle:基于数据挖掘探讨王彦刚治疗胃食管反流病的临证经验
- Author:
Jingjing LYU
1
;
Haiyan BAI
;
Zhixiu HAN
;
Zeqi YANG
;
Lishan LU
;
Yan'gang WANG
Author Information
1. 河北省中医院脾胃病科,河北 石家庄 050011
- Keywords:
gastroesophageal reflux disease(GERD);
stagnated heat injuring yin;
clearing heat and nourishing yin;
Sepiae Endoconcha(Haipiaoxiao);
Fritillariae Thunbergii Bulbus(Zhebeimu);
Scutellariae Radix(Huangqin);
Coptidis Rhizoma(Huanglian);
data mining;
Wang Yan'g
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(6):1503-1509
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical experience of Professor Wang Yan'gang in treating gastroesophageal reflux disease(GERD)using data mining methods.Methods SPSS 23.0 was used to statistically analyze the frequency,properties,flavors,and meridian tropism of Chinese herbal medicines in the prescriptions of effective GERD cases treated by Professor Wang Yan'gang in outpatient clinics from January 2020 to December 2022.Cluster analysis,factor analysis,and association rule analysis were performed on the relevant drugs.Results A total of 294 outpatient prescriptions for the treatment of GERD were collected,including 174 Chinese herbal medicines.The top 10 frequently-used drugs were Sepiae Endoconcha(Haipiaoxiao),Fritillariae Thunbergii Bulbus(Zhebeimu),Scutellariae Radix(Huangqin),Coptidis Rhizoma(Huanglian),Pinelliae Rhizoma Praeparatum Cum Alumine(Qingbanxia),Arecae Semen Tostum(Chaobinglang),Artemisiae Scopariae Herba(Yinchen),Gypsum Fibrosum(Shigao),Aurantii Fructus Immaturus(Zhishi),and Magnoliae Officinalis Cortex(Houpo).After cluster analysis,factor analysis,and association rule analysis,16 commonly-used herb pairs,such as Huangqin-Huanglian,Citri Reticulatae Pericarpium(Chenpi)-Zhuru(Bambusae Caulis in Taenia),Haipiaoxiao-Zhebeimu,Shichangpu(Acori Tatarinowii Rhizoma)-Yujin(Curcumae Radix),and Zhishi-Houpo were identified,and 9 herb groups such as"Huangqin,Huanglian,Yinchen"and"Chenpi,Zhuru,Qingbanxia"were obtained.Factor analysis was performed on 22 drugs with a usage frequency more than 110 times,and then 6 common factors were extracted after principal component analysis.Conclusion In differentiating and treating GERD,Professor Wang Yan'gang suggests that stagnated heat injuring yin should be taken as the core pathogenesis,and therapy of clearing heat and nourishing yin should be used as the core treatment method.Additionally,auxiliary methods such as soothing the throat,regulating the liver and stomach,and nourishing the heart and spirit can be adopted according to the accompanying symptoms during the disease progression.
