Clinical Efficacy of Jiedu Bushen Huoxue Formula in Treating Bone and Joint Damage Associated with Hepatolenticular Degeneration and Its Impact on Bone Metabolism Indicators
10.13359/j.cnki.gzxbtcm.2025.06.012
- VernacularTitle:解毒补肾活血方治疗肝豆状核变性相关骨关节损害的临床疗效及对骨代谢指标的影响
- Author:
Shan WANG
1
;
Xiang FANG
Author Information
1. 合肥华安脑科医院神经内科,安徽 合肥 230041
- Keywords:
hepatolenticular degeneration(HLD);
bone and joint damage;
Jiedu Bushen Huoxue Prescription;
bone mineral density;
bone metabolism indicators;
therapeutic mechanism
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(6):1378-1384
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and mechanism of Jiedu Bushen Huoxue Prescription in intervening bone and joint damage associated with hepatolenticular degeneration(HLD)by investigating its effect on improving HLD-related bone and joint damage symptoms and on bone metabolism indicators.Methods From March 2022 to August 2022,a total of 57 patients diagnosed with HLD-related bone and joint damage admitted to the First Department of Neurology,the First Affiliated Hospital of Anhui University of Chinese Medicine were selected as the study subjects.The patients were randomly divided into an observation group(29 cases)and a control group(28 cases)using a random number table.The control group was given conventional decopper therapy combined with Alfacalcidol Soft Capsules and Alendronate Sodium Tablets,while the observation group was given additional treatment with Jiedu Bushen Huoxue Prescription based on the control group's regimen.The treatment course lasted 8 weeks.Before and after treatment,changes in the Oswestry Disability Index(ODI)score,Numerical Rating Scale(NRS)pain score,and bone mineral density(BMD)values in the two groups were observed to evaluate overall efficacy.Additionally,serum levels of interleukin 1β(IL-1β),interleukin 6(IL-6),C-terminal telopeptide of type I collagen(β-CTX),and 1,25-dihydroxyvitamin D3[1,25-(OH)2D3]in the two groups were measured before and after treatment to observe the impact on bone metabolism indicators.Results(1)After treatment,the ODI scores and NRS pain scores in both groups were significantly decreased compared to those before treatment(P＜0.05),and the decrease in the observation group was more obvious than that in the control group(P＜0.05).(2)After treatment,the BMD values of the bilateral femoral neck and lumbar vertebrae 2-4(L2-L4)in both groups were significantly increased compared to those before treatment(P＜0.05),and the increase in the observation group was more obvious than that in the control group(P＜0.05).(3)After treatment,the serum levels of IL-1β,IL-6,and β-CTX in both groups were significantly decreased(P＜0.05),while the serum levels of 1,25-(OH)2D3 were significantly increased(P＜0.05)compared to those before treatment.The decrease in IL-1β,IL-6,and β-CTX levels and the increase in 1,25-(OH)2D3 levels in the observation group were superior to those in the control group(P＜0.05).Conclusion Jiedu Bushen Huoxue Prescription has certain effect on improving the symptoms of the patients with HLD-related bone and joint damage,and it is effective on significantly alleviating bone and joint pain and improving BMD and joint function.Its mechanism may be related to the improvement of relevant bone metabolism indicators.
