Ferroptosis Mechanism of Knee Osteoarthritis and Its Progress in Traditional Chinese Medicine Intervention
10.13359/j.cnki.gzxbtcm.2025.05.037
- VernacularTitle:膝关节骨性关节炎的铁死亡机制及其中医药干预进展
- Author:
Feiyu HAN
1
;
Yujing CAO
;
Zihan LIN
;
Yinlong WANG
;
Wuyue TONG
Author Information
1. 河南中医药大学骨伤学院,河南 郑州 450000
- Keywords:
knee osteoarthritis;
ferroptosis;
chondrocytes;
traditional Chinese medicine;
Drynariae Rhizoma;
Duhuo Jisheng Decoction
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(5):1290-1296
- CountryChina
- Language:Chinese
-
Abstract:
Knee osteoarthritis(KOA)is a common musculoskeletal disease,and ferroptosis is a new type of programmed cell death involving iron ions.This paper summarized the relationship between the pathological changes of ferroptosis and the onset of KOA,and reviewed the progress of traditional Chinese medicine(TCM)intervention in KOA based on the pathological changes of ferroptosis.The pathological changes of ferroptosis are mainly related to the imbalance of amino acid antioxidant system,iron metabolism disorder and lipid peroxide accumulation.The cystine/glutamate antiporter(System XC-),glutathione(GSH)and glutathione peroxidase 4(GPX4)are the core targets for regulating ferroptosis,involving the main signaling pathways for studying the TCM intervention of KOA via ferroptosis.Single herbs such as Drynariae Rhizoma,Scutellariae Barbatae Herba,Epimedii Folium,Astragali Radix,Ligustri Lucidi Fructus,and Achyranthis Bidentatae Radix,and multi-herb formulae such as Duhuo Jisheng Decoction and Yougui Pills,can inhibit the ferroptosis of chondrocytes through multiple targets and multiple pathways,thus treating KOA.The research of the TCM intervention on the ferroptosis of chondrocytes and its associated signaling pathways can provides a novel approach for expanding the TCM therapy of KOA.
