Exploring the Pathogenic Mechanism and Treatment Approach of Uremia-Induced Myocardial Injury in Traditional Chinese and Western Medicine
10.13359/j.cnki.gzxbtcm.2025.04.032
- VernacularTitle:尿毒症心肌损伤的中西医致病机制及治疗思路探讨
- Author:
Jinfeng SHEN
1
;
Fang HU
;
Fuzhen WANG
;
Silin LIAO
;
Hui JIANG
;
Ziyou YAN
Author Information
1. 福建医科大学附属龙岩市第一医院,福建龙岩 364000
- Keywords:
uremia-induced myocardial injury;
healthy-qi deficiency resulting in latent pathogenic turbidity;
pathogenic turbidity;
PINK1/Parkin-mediating;
mitochondrial autophagy;
supporting healthy-qi to eliminate pathogenic turbidity
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(4):1013-1017
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial injury is the leading cause of death in uremic patients.PINK 1/Parkin-mediated mitochondrial autophagy is involved in the progression of myocardial injury.In recent years,pathogenic turbidity has been gradually accepted as a representative of a new type of toxic pathogens by the researchers of traditional Chinese medicine(TCM).This paper sorts out literature about pathogenic turbidity,analyzes the etiological and pathogenic characteristics of pathogenic turbidity,and suggests that the pathogenesis of uremia-induced myocardial injury can be more comprehensively clarified from the perspective of healthy-qi deficiency resulting in latent pathogenic turbidity.In the patients with uremia,the down-regulation of PINK1/Parkin causes the weakening of mitochondrial autophagy,which leads to the elevation of levels of reactive oxygen species(ROS)and inflammatory factors,and eventually causes the injury of myocardial cell.The above pathogenic mechanism is similar to the process of traditional Chinese medicine(TCM)in which the deficiency of the healthy-qi(in particular kidney deficiency)results in the production of the pathogenic turbidity(showing as dampness,blood stasis,phlegm,toxin and so on)and then causes the pathogenic turbidity hide in vessels and collaterals and gradually injure the heart vessels,and eventually results in the deficiency of heart vessels.The mitochondrial autophagy mechanism mediated by the PINK1/Parkin pathway is suitalbe for explaining the TCM pathogenesis of uremia-induced myocardial injury,characterized by healthy-qi deficiency resulting in latent pathogenic turbidity,and also is suitable for interpretating the principle of supporting healthy-qi to eliminate pathogenic turbidity for treating uremia-induced myocardial injury.Under the guidance of the theory of health y-qi deficiency and turbid pathogens in TCM,the development of specific PINK 1/Parkin agonists may expand the approach for the treatment of uremia-induced myocardial injury.
