Study on the Correlation Between Traditional Chinese Medicine Syndrome Types and Serum NLR,PCT,CRP and IL-6 in Patients with Acute Pelvic Inflammatory Diseases
10.13359/j.cnki.gzxbtcm.2025.04.005
- VernacularTitle:急性盆腔炎性疾病患者中医证型与血清NLR、PCT、CRP、IL-6的相关性研究
- Author:
Donglan CHEN
1
;
Xiao'ou ZHU
Author Information
1. 临海市中医院,浙江临海 317000
- Keywords:
acute pelvic inflammatory disease(APID);
traditional Chinese medicine(TCM)syndrome types;
excessive heat-toxin syndrome;
dampness-heat-stasis obstruction syndrome;
neutrophil-to-lymphocyte ratio(NLR);
procalcitonin(PCT);
C-reactive protein(CRP);
interleukin
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(4):827-832
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between traditional Chinese medicine(TCM)syndrome types and serum level of neutrophil-to-lymphocyte ratio(NLR),procalcitonin(PCT),C-reactive protein(CRP),and interleukin 6(IL-6)in the patients with acute pelvic inflammatory disease(APID),and to assess the diagnostic value of NLR,PCT,CRP,and IL-6 for APID patients.Methods A total of 110 patients with APID who met the inclusion criteria and were admitted to the Gynecology Outpatient and Inpatient Departments of Linhai Hospital of Traditional Chinese Medicine from January 2020 to March 2024 were selected,and were classified into 60 cases of excessive heat-toxin syndrome and 50 cases of dampness-heat-stasis obstruction syndrome according to the criteria of TCM syndrome differentiation.The levels of serum indicators of NLR,PCT,CRP and IL-6,diameter of inflammatory masses,and depth of pelvic effusion were compared between the two TCM syndrome types,and the correlation of serum indicator levels with inflammatory mass diameter and depth of pelvic effusion was analyzed.Moreover,the correlation of serum indicator levels,diameter of inflammatory masses,and depth of pelvic effusion with the prognosis of APID and their correlation with TCM syndrome types were investigated.Results Levels of serum indicators of NLR,PCT,CRP,and IL-6,inflammatory mass diameter and depth of pelvic effusion in the patients of excessive heat-toxin syndrome were significantly higher than those in the patients of dampness-heat-stasis obstruction syndrome(P＜0.05 or P＜0.01).Results of Spearman correlation analysis showed that the levels of serum indicators of NLR,PCT,CRP,and IL-6 were positively correlated with the diameter of inflammatory masses and depth of pelvic effusion(P＜0.01).Results of Logistic regression analysis showed that the serum indicator levels,diameter of inflammatory masses,and depth of pelvic effusion were negatively correlated with APID prognosis(P＜0.05 or P＜0.01).Results of multivariate logistic regression showed that the serum indicator levels,diameter of inflammatory masses and depth of pelvic effusion were positively correlated with the excessive heat-toxin syndrome and dampness-heat-stasis obstruction syndrome(P＜0.05 or P＜0.01).Conclusion The levels of serum NLR,PCT,CRP and IL-6 are higher in the patients of excessive heat-toxin syndrome than those of dampness-heat-stasis obstruction syndrome.Serum NLR,PCT,CRP and IL-6 may serve as the potential biological indicators the TCM syndrome differentiation of APID in clinic.
