Data Mining of Traditional Chinese Medicine Syndrome Types of Thalassemia in Pregnancy and the Medication Rules of Chinese Medicine
10.13359/j.cnki.gzxbtcm.2025.03.036
- VernacularTitle:妊娠合并地中海贫血中医证型及中药用药规律的数据挖掘
- Author:
Lishan SU
1
;
Yanfang LI
Author Information
1. 广州中医药大学,广东广州 510405
- Keywords:
thalassemia in pregnancy;
Chinese medicine compound;
qi deficiency syndrome;
Atractylodis Macrocephalae Rhizoma;
Codonopsis Radix;
Poria;
Astragali Radix;
Dioscoreae Rhizoma;
Asini Corii Colla;
Bazhen Decoction;
Guipi Decoction;
data mining
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(3):782-788
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively analyze the traditional Chinese medicine(TCM)syndrome types of thalassemia in pregnancy and to explore the medication rules of Chinese medicine for its treatment by data mining methods.Methods From February 2022 to February 2024,we collected the case records of pregnant women with thalassemia who were effectively treated with Chinese medicine compound in the outpatient clinic of the First Affiliated Hospital of Guangzhou University of Chinese Medicine.The TCM syndrome types and medication rules of Chinese medicine were analyzed by using data mining methods such as frequency analysis,association rule analysis,and clustering analysis.Results The results of analysis of TCM syndrome types showed that pregnant women with thalassemia were frequently differentiated as qideficiency syndrome.A total of 64 prescriptions were included in this study,including 51 Chinese herbal medicines.The high-frequency Chinese herbal medicines used more than 35 times were Atractylodis Macrocephalae Rhizoma(Baizhu),Codonopsis Radix(Dangshen),Poria(Fuling),Astragali Radix(Huangqi),Dioscoreae Rhizoma(Shanyao),Asini Corii Colla(Ej iao),Glycyrrhizae Radix et Rhizoma Praeparata cum Melle(Zhigancao).The Chinese herbal medicine used in these prescriptions were mainly sweet and mild in nature,usually had the meridian tropism of spleen meridian and lung meridian,and had the main therapeutic action for preventing miscarriage.The analysis of association rules showed that"Dangshen-Baizhu","Fuling-Dangshen,Baizhu",and"Huangqi-Fuling,Dangshen,Baizhu"were the core Chinese herbal medicine combinations.The cluster analysis yielded a total of five groups of clustered Chinese herbal medicines.Conclusion Pregnant women with thalassemia are frequently differentiated as qi deficiency syndrome.The treatment of thalassemia in pregnancy with Chinese herbal medicine follows the principle of reinforcement of both qiand blood,simultaneous treatment of the heart and spleen,and nourishing without stagnation.Chinese herbal medicines for the treatment are usually mild and sweet,and the prescriptions are formulated usually based on the modification of Bazhen Decoction or Guipi Decoction for tonification,together with the herbs for separately expelling the internal pathogens of deficiency-heat,water-dampness and blood stasis,and the external pathogen of wind,cold,dampness and heat,thus to ensure the safety of the mother and the fetus.
