Role of Apolipoprotein E4 in the Pathogenesis of Alzheimer's Disease and Thoughts for Early Intervention with Traditional Chinese Medicine
10.13359/j.cnki.gzxbtcm.2025.02.037
- VernacularTitle:载脂蛋白E4在阿尔茨海默病发病机制中的作用及中医药早期干预思路
- Author:
Jingwen LIU
1
;
Zijia ZHANG
;
Kaili WANG
;
Jiayan HUANG
;
Weimin LI
;
Xinxin ZHOU
Author Information
1. 广州中医药大学,广东广州 510006
- Keywords:
Alzheimer's disease;
apolipoprotein E4(APOE4);
metabolic disorders;
deficiency in origin and excess in superficiality;
prevention before illness;
traditional Chinese medicine intervention
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(2):512-517
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is a progressive neurodegenerative disease with hidden onset.Recent researches have shown that apolipoprotein E4(APOE4)is a high-risk genetic factor of AD,and the clinical symptoms in APOE4 genotype AD patients are closely related to metabolic disorders.This paper reviewed the role of APOE4 in the pathogenesis of AD,and it is indicated that APOE4 contributes to the injury of the cerebral blood-brain barrier,is associated with the disorder of cerebral glucose and lipid metabolism,and leads to the damage of the scavenging ability of microglia.Moreover,this paper explored the approach of early intervention of AD with traditional Chinese medicine(TCM)based on the APOE4 pathogenesis.Based on the pathogenesis of AD being deficiency in origin and excess in superficiality,and under the guidance of the principle of prevention before illness in TCM,it is proposed that early TCM intervention for APOE4 genotype AD patients with metabolic disorders can be performed through improving the phlegm-dampness constitution,by focusing on insulin resistance-related indicators,and with traditional Chinese drug therapy based on syndrome differentiation alone or together with comprehensive management of exercises,diet control and drug interventions,thus to reduce or delay the onset of APOE4 genotype AD.
