Exploration of Chinese Herbal Medicines in the Prevention and Treatment of Colorectal Cancer by Influencing the Post-Translational Modification Process
10.13359/j.cnki.gzxbtcm.2025.02.036
- VernacularTitle:中药通过影响翻译后修饰过程防治结直肠癌的探讨
- Author:
Yingying LIANG
1
;
Zhen JIA
;
Wanting FU
;
Linlin LU
Author Information
1. 广州中医药大学中药学院,广东广州 510006
- Keywords:
colorectal cancer;
post-translational modification;
Chinese herbal medicine;
Coptidis Rhizoma;
Euodiae Fructus;
Scutellariae Radix;
ubiquitination;
ubiquitination-like;
acetylation
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(2):505-511
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the post-translational modification in epigenetics has drawn the attention of the researchers,and is expected to become the important direction for tumor pharmacology research in future.Chinese herbal medicine has the advantages of less side effects and better efficacy,and has shown good prospects in the research of prevention and treatment of colorectal cancer.This paper outlined the types of post-translational modifications in epigenetics and their roles in the progression of colorectal cancer,and explored the possible mechanisms of single Chinese herbal medicine and Chinese herbal compounds in the treatment of colorectal cancer by influencing post-translational modifications.In the progression of colorectal cancer,the post-translational modifications such as ubiquitination,ubiquitination-like,acetylation,crotonylation and glycylation were involved.The Chinese medicinal active ingredients from Coptidis Rhizoma,Euodiae Fructus,Scutellariae Radix,Curcumae Longae Rhizoma,etc.,and Chinese herbal compounds of Yiliu Decoction and Teng Long Buzhong Decoction have all shown certain effects for the prevention and treatment of colorectal cancer by participating in post-translational modifications.The in-depth exploration of the therapeutic mechanism of Chinese herbal medicine in the prevention and treatment of colorectal cancer and the development of new Chinese medicinal preparations from the perspective of post-translational modification are expected to become a new direction for the future research on the mechanism of anti-colorectal cancer and on the application of anti-cancer agents.
