Observation on the Clinical Efficacy of Therapy of Resolving Blood Stasis and Tranquilizing Mind for Insomnia with Internal Blockage of Blood Stasis Type
10.13359/j.cnki.gzxbtcm.2025.02.012
- VernacularTitle:化瘀安神法治疗瘀血内阻型不寐的临床疗效观察
- Author:
Junjie CHAI
1
;
Junfan WEI
;
Yang ZHANG
;
Hualu FU
;
Sichen LIU
;
Zichen OUYANG
;
Jingbao HU
Author Information
1. 广州中医药大学附属宝安中医院,广东深圳 518033;广州中医药大学研究生院,广东广州 510006
- Keywords:
insomnia;
internal blockage of blood stasis;
resolving blood stasis and tranquilizing mind;
Xuefu Zhuyu Decoction;
depression;
anxiety;
clinical efficacy;
safety
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(2):336-342
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of therapy of resolving blood stasis and tranquilizing mind in the treatment of insomnia with internal blockage of blood stasis type.Methods A parallel randomized controlled trial was conducted on 88 cases of insomnia patients with internal blockage of blood stasis type who admitted to Bao'an Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine from January 2024 to June 2024.The patients were randomly divided into an observation group and a control group,with 44 cases in each group.The observation group was treated with the self-made Huayu Anshen Prescription(modified Xuefu Zhuyu Decoction)orally following the therapy of resolving blood stasis and tranquilizing mind,while the control group was treated with Dexzopiclone Tablets orally.The course of treatment for the two groups covered four weeks.The changes in the scores of traditional Chinese medicine(TCM)syndrome,Pittsburgh Sleep Quality Index(PSQI),Self-Rating Depression Scale(SDS),and Self-Rating Anxiety Scale(SAS)in the two groups before and after treatment were observed,and then the clinical efficacy and medication safety of the patients in the two groups were evaluated.Results(1)After four weeks of treatment,the total effective rate of the observation group was 86.36%(38/44)and that of the control group was 70.45%(31/44),and the intergroup comparison showed that the clinical efficacy of the observation group was significantly superior to that of the control group,the difference being statistically significant(χ2=8.080,P<0.05).(2)After treatment,the scores of TCM syndrome,PSQI,SDS,and SAS of patients in the two groups were all significantly decreased compared with those before treatment(P<0.01),and the decrease in the observation group was significantly superior to that in the control group,the differences all being statistically significant(P<0.05).(3)During the treatment,there were no obvious adverse reactions occurred in the two groups,with higher safety.Conclusion Therapy of resolving blood stasis and tranquilizing mind for treating insomnia with internal blockage of blood stasis type can effectively alleviate patients'clinical symptoms,improve their sleep quality and relieve depression and anxiety,with stronger clinical efficacy and higher safety.
