Discussion on the Prevention and Treatment of Endocrine Therapy Associated Osteoporosis in Breast Cancer Based on the Theory of"Liver and Kidney Sharing the Common Source"
10.13359/j.cnki.gzxbtcm.2025.02.006
- VernacularTitle:基于"肝肾同源"理论防治乳腺癌内分泌治疗相关性骨质疏松症的思路探讨
- Author:
Zishen LIU
1
;
Yingying ZHENG
;
Mengqi YUAN
;
Ganlin ZHANG
;
Guowang YANG
Author Information
1. 首都医科大学附属北京中医医院,北京 100010
- Keywords:
liver and kidney sharing the common source;
breast cancer;
endocrine therapy;
osteoporosis;
nourishing liver and kidney;
Liuwei Dihuang Pills;
Duhuo Jisheng Decoction;
Zuogui Pills
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(2):293-297
- CountryChina
- Language:Chinese
-
Abstract:
Endocrine therapy is mainly used as preoperative neoadjuvant therapy and postoperative adjuvant therapy for breast cancer patients and as salvage therapy for advanced breast cancer patients.Osteoporosis is the common adverse reaction of endocrine therapy for breast cancer,which seriously affects the quality of life of the patients.The theory of"liver and kidney sharing the common source"is closely related to the etiology,pathogenesis and therapeutic principle of osteoporosis.It is believed that the pathogenesis of endocrine therapy associated osteoporosis in breast cancer is most closely related to liver and kidney,and is characterized by deficiency in origin and excess in superficiality.Deficiency in origin manifests as deficiency of liver and kidney,and excess in superficiality manifests as blood stasis blocking collaterals.Chinese herbal medicine with the actions of nourishing liver and kidney can be used for interventions of various stages of endocrine therapy for breast cancer.In the stage of preoperative neoadjuvant therapy,Chinese herbal medicine intervention focuses on inhibiting cancer,so as to achieve synergistic anticancer actions with neoadjuvant therapy;the intervention can also be supplemented by medicine for supporting healthy qi with modified Liuwei Dihuang Pills,thus to reduce the incidence of adverse reactions.In the stage of postoperative adjuvant therapy,Chinese herbal medicine intervention focuses on supporting healthy qi,so as to promote the recovery of body functions and prevent the occurrence of osteoporosis,and modified treatment with Duhuo Jisheng Decoction or Zuogui Pills can be chosen.In the advanced stage of salvage treatment,Chinese herbal medicine intervention focuses on supporting healthy qi,and medicines for nourishing liver and kidney,strengthening muscles and bones,and activating qi and blood circulation to relieve pain can be chosen;in addition,medicinals with affinity to flesh and blood can be added to enhance the actions of nourishing liver and kidney.
