Study on Correlation of the Degree of Left Anterior Descending Artery Stenosis with the Prognosis and Traditional Chinese Medicine Syndrome Types of Wellens'Syndrome Patients
10.13359/j.cnki.gzxbtcm.2025.02.004
- VernacularTitle:Wellens综合征左前降支狭窄程度及预后与中医证型的相关性研究
- Author:
Chunnong WEI
1
;
Huiwen XIE
Author Information
1. 广州中医药大学第一临床医学院,广东广州 510405
- Keywords:
Wellens'syndrome;
the degree of left anterior descending artery stenosis;
prognosis;
electrocardiogram classification;
traditional Chinese medicine syndrome types;
heat toxin resulting in blood stasis syndrome;
turbid phlegm resulting in blood stasis syndr
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(2):277-282
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of the degree of left anterior descending artery stenosis of coronary artery with the prognosis and traditional Chinese medicine(TCM)syndrome types of Wellens'syndrome(WS)patients.Methods A retrospective analysis was conducted on 70 patients who were hospitalized in the Cardiology Department of the First Affiliated Hospital of Guangzhou University of Chinese Medicine from September 2021 to September 2023,and the patients all met the diagnostic criteria of WS and had completed coronary artery angiography.The clinical data of the patietns was collated and then a database was constructed.The patients were differentiated into four TCM syndrome types,namely qi deficiency and blood stasis syndrome,qi and yin deficiency syndrome,heat toxin resulting in blood stasis syndrome,and turbid phlegm resulting in blood stasis syndrome.The analysis was performed for the general information,distribution of TCM syndrome types,Gensini score for the degree of left anterior descending artery stenosis,and thrombolysis in myocardial infarction(TIMI)risk score for the prognosis,and then the correlation of the degree of left anterior descending artery stenosis with the prognosis and TCM syndrome types of WS patients was explored.Results(1)The analysis of the distribution of TCM syndrome types showed that among the 70 WS patients,heat toxin resulting in blood stasis syndrome accounted for the largest proportion of 37.14%(26/70),while qi deficiency and blood stasis syndrome accounted for the smallest proportion of 12.86%(9/70).The TCM syndromes types ranking in descending order were as follows:heat toxin resulting in blood stasis syndrome>turbid phlegm resulting in blood stasis syndrome>qi and yin deficiency syndrome>qi deficiency and blood stasis syndrome.(2)There was no statistically significant difference in the distribution of gender and age among WS patients with various TCM syndrome types(P>0.05).(3)The differences in Gensini score among WS patients with various TCM syndrome types groups were statistically significant(P<0.01),and the Gensini scores were higher in the heat toxin resulting in blood stasis syndrome and turbid phlegm resulting in blood stasis syndrome,particularly in turbid phlegm resulting in blood stasis syndrome.Post-hoc pairwise comparisons showed that the Gensini scores in heat toxin resulting in blood stasis syndrome group and turbid phlegm resulting in blood stasis syndrome group were both significantly higher than those in qi deficiency and blood stasis syndrome group(P<0.05).No statistically significant differences were presented in TIMI risk score among WS patients with various TCM syndrome types(P<0.05).Post-hoc pairwise comparisons show that the TIMI risk score of heat toxin resulting in blood stasis syndrome group was higher than that of the qi deficiency and blood stasis syndrome group(P<0.05),while there was no statistically significant difference among the rest groups(P>0.05).(4)The Gensini score and TIMI risk score of patients with electrocardiogram(ECG)classification WS-Ⅱ were higher than those of patients with ECG classification WS-Ⅰ(P<0.05).(5)Correlation analysis of the TIMI risk score and Gensini score revealed that there existed a correlation between them(RS=0.258,P<0.05).Conclusion In patients with WS,the Gensini score is higher in those with heat toxin resulting in blood stasis syndrome and turbid phlegm resulting in blood stasis syndrome,indicating that the left anterior descending artery stenosis is severer.And there is a correlation between Gensini score and TIMI risk score.
