Correlation Between Traditional Chinese Medicine Syndrome Types and Laboratory Findings in Patients with Primary Sj?gren's Syndrome:An Analysis of 326 Cases
10.13359/j.cnki.gzxbtcm.2025.02.001
- VernacularTitle:326例原发性干燥综合征中医证型与实验室检测指标的相关性研究
- Author:
Wanmei NA
1
;
Dan WANG
;
Hao ZHAO
;
Yu HUANG
Author Information
1. 上海中医药大学附属岳阳中西医结合医院风湿病科,上海 200437
- Keywords:
primary Sj?gren's syndrome;
laboratory findings;
immunology;
inflammatory cytokines;
traditional Chinese medicine syndrome types;
correlation
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(2):261-265
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of traditional Chinese medicine(TCM)syndrome types in patients with primary Sj?gren's syndrome(PSS),and to explore the correlation between TCM syndrome types and laboratory findings of immunological parameters and inflammatory cytokines.Methods A retrospective study was conducted on 326 patients with PSS who attended the Department of Rheumatology of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,from January 2018 to December 2022.Analysis was carried out for the distribution of TCM syndrome types,namely yin deficiency and blood dryness syndrome,deficiency of qi and yin syndrome,internal retention of damp-heat syndrome,and stagnant heat in the collateral syndrome,in PSS patients.The gender,age of onset,and duration of disease of PSS patients with different TCM syndrome types were compared.And then an exploration was performed in the correlation between TCM syndrome types and laboratory findings of Sj?gren's syndrome antigen A antibody(anti-SSA),Sj?gren's syndrome antigen B antibody(anti-SSB),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),immunoglobulin G(IgG),immunoglobulin A(IgA),interleukin 6(IL-6),complement 3(C3)and complement 4(C4).Results(1)The analysis of the distribution of TCM syndrome types showed that among the 326 patients,106 cases(32.5%)were differentiated as internal retention of damp-heat syndrome,which accounted for the most,and then came yin deficiency and blood dryness syndrome(84 cases,25.8%),stagnant heat in the collateral syndrome(78 cases,23.9%),and deficiency of qi and yin syndrome(58 cases,17.8%)in descending order.(2)There was no statistically significant difference in the gender among the PSS patients with different TCM syndrome types(P>0.05),but the differences of age of onset and the duration of disease among the PSS patients with different TCM syndrome types were statistically significant(P<0.05).The distribution of duration of disease and age of onset in the PSS patients with yin deficiency and blood dryness syndrome,deficiency of qi and yin syndrome,and stagnant heat in the collateral syndrome,internal retention of damp-heat syndrome was in descending order.(3)The analysis of the correlation between TCM syndrome types and laboratory findings showed that yin deficiency and blood dryness syndrome was positively correlated with anti-SSB,IgA,IgG,and C4;deficiency of qi and yin syndrome was positively correlated with anti-SSB,IgG,and C4;internal retention of damp-heat syndrome was positively correlated with CRP,ESR,IL-6,anti-SSA,and IgA;stagnant heat in the collateral syndrome was positively correlated with CRP,ESR,IL-6,and anti-SSA.The differences were all statistically significant(P<0.05 or P<0.01).Conclusion The patients with PSS are usually differentiated as internal retention of damp-heat syndrome,patients with yin deficiency and blood dryness syndrome and deficiency of qi and yin syndrome usually have longer duration of disease and older age of onset,and the patients with internal retention of damp-heat syndrome and stagnant heat in the collateral syndrome usually have shorter duration of disease and younger age of onset.The laboratory findings such as immunological parameters and inflammatory cytokine are correlated with TCM syndrome types of PSS patients to some extent,which will supply guidance for the clinical differentiation of TCM syndromes of PSS.
