Exploration on Pathogenesis of Type 2 Diabetes Mellitus and Thoughts for Its Prevention Based on Vigorous Fire Consuming Qi and Inflammation-Mitochondrial Damage
10.13359/j.cnki.gzxbtcm.2024.12.036
- VernacularTitle:基于"壮火食气"与"炎症-线粒体损伤"探讨2型糖尿病的发病机制和防治思路
- Author:
Wen-Qian YU
1
;
Wei-Jun HUANG
;
Qiang FU
Author Information
1. 北京中医药大学东直门医院,北京 100700
- Keywords:
vigorous fire consuming qi;
type 2 diabetes mellitus;
inflammation;
mitochondrial damage;
replenishing qi,clearing heat and activating blood;
integrated Chinese and western medicine
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(12):3330-3335
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes mellitus(T2DM)is a common metabolic disease with serious complications,and its pathogenesis and evolution are complicated.This paper discussed the pathogenesis of T2DM and thoughts for its prevention from the mechanism of"vigorous fire consuming qi"in traditional Chinese medicine(TCM)and from the mechanism of"inflammation-mitochondrial damage"in western medicine."Vigorous fire consuming qi"reflects the characteristics of pathogenesis of T2DM:"vigorous fire"becomes an important factor in the pathogenesis of T2DM,and"consuming qi"reveals the pathogenic process,indicating that the fundamental pathogenesis of T2DM is characterized by"deficiency of healthy qi"as the root and take,and"stagnated heat"as the branch."Vigorous fire consuming qi"also reveals that the evolution of pathogenesis is in a vicious cycle of"vigorous fire-qi deficiency-phlegm and blood stasis",in which phlegm and blood stasis boost the vigorous fire.Based on modern clinical research and basic research,the hypothesis of inflammation-mitochondrial damage in T2DM was proposed in this paper,and it was pointed out that the mitochondria is the key therapeutic target to break the cycle of inflammation-mitochondrial damage,and protecting mitochondria is the underlying biological essence of the therapeutic principle of"replenishing qi,clearing heat and activating blood".The exploration on the pathogenesis of T2DM by combining the TCM pathogenesis of"vigorous fire consuming qi"with the mechanism of"inflammation-mitochondrial damage"in western medicine will be expected to provide new perspectives for the study of prevention and treatment of T2DM with integrated Chinese and western medicine.
