Clinical Efficacy Observation of Acupuncture Combined with Western Medicine in the Treatment of Endometriosis of Cold Accumulation Causing Blood Stasis Type
10.13359/j.cnki.gzxbtcm.2024.12.021
- VernacularTitle:针刺联合西药治疗寒凝血瘀型子宫内膜异位症的临床疗效观察
- Author:
Zi-Ying ZHU
1
;
Hui-Ying WU
;
Ping ZHANG
;
Li-Juan YANG
Author Information
1. 江西中医药大学,江西南昌 330004
- Keywords:
acupuncture;
Mifepristone Tablets;
endometriosis;
cold accumulation causing blood stasis;
vascular endothelial growth factor;
matrix metalloproteinase-9;
prostaglandin E2;
clinical efficacy
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(12):3222-3227
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of acupuncture combined with western medicine in the treatment of endometriosis(EMs).Methods A total of 82 patients with EMs of cold accumulation causing blood stasis type were randomly divided into observation group and control group,41 patients in each group.Mifepristone and Guizhi Fuling Capsules were oral administration in the control group,and the observation group was treated with acupuncture based on the treatment of the control group.patients in the two groups were all treated for three menstrual cycles.After three months of treatment,the clinical efficacy of the two groups was evaluated,and the changes in the Visual Analogue Scale(VAS)and Self-Rating Anxiety Scale(SAS)of pain,as well as traditional Chinese medicine(TCM)syndrome scores before and after treatment were observed.The changes of serum levels of vascular endothelial growth factor(VEGF),matrix metalloproteinase-9(MMP-9)and prostaglandin E2(PGE2)between the two groups before and after treatment were compared.Results(1)The total effective rate was 92.68%(38/41)in the observation group and 75.61%(31/41)in the control group.The efficacy of the observation group was superior to that of the control group,and the difference was statistically significant(P＜0.05).(2)After treatment,VAS scores and SAS scores of patients in the two groups were improved significantly,and the improvement in the observation group was significantly superior to that in the control group,and the differences were statistically significant(P＜0.05).(3)After treatment,the TCM syndrome scores of the two groups were significantly improved,and the improvement in the observation group was significantly superior to that in the control group,with statistically significant differences(P＜0.05).(4)After treatment,the serum levels of VEGF,MMP-9 and PGE2 of the two groups of patients were improved significantly,and the improvement in the observation group was significantly superior to that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Acupuncture combined with western medicine in the treatment of EMs can significantly improve pain,relieve anxiety,reduce clinical symptoms of patients,and regulate their VEGF,MMP-9 and PGE2 levels,with remarkable clinical efficacy.
