Study on the Effect of Niujiao Dihuang Jiedu Decoction on Liver Function and Coagulation Function of Patients with Acute-on-Chronic Liver Failure
10.13359/j.cnki.gzxbtcm.2024.12.011
- VernacularTitle:牛角地黄解毒汤对慢加急性肝衰竭患者肝脏功能及凝血功能的影响研究
- Author:
Si-Chen LIU
1
;
Jing-Bao HU
;
Huo-Cheng YE
;
Jun-Jie CHAI
;
Lin-Ya NI
;
Xiao-Min HUANG
;
Yan-Ping LU
Author Information
1. 广州中医药大学附属宝安中医院,广东深圳 518100
- Keywords:
Niujiao Dihuang Jiedu Decoction;
Xijiao Dihuang Decoction;
integration of Chinese and western medicine;
acute-on-chronic liver failure;
liver function;
prothrombin time
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(12):3161-3166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of the integrative Chinese and western medicine therapy with the utilization of Niujiao Dihuang Jiedu Decoction(derived from the modified Xijiao Dihuang Decoction)in the treatment of acute-on-chronic liver failure(ACLF).Methods Sixty patients with ACLF of toxic-heat-stasis stagnation type were randomly divided into the trial group and the control group,with 30 patients in each group.The control group was given western medicine comprehensive treatment(including etiologic treatment,liver-protecting treatment and symptomatic and supportive treatment),while the trial group was treated with Niujiao Dihuang Jiedu Decoction on the basis of treatment for the control group,and the courses of treatment covered four weeks.The changes of liver function indicators and coagulation function indicators of the patients in the two groups before and after treatment were observed,and the clinical efficacy of the patients in the two groups after treatment was evaluated.Results(1)During the trial,there were two cases in the trial group and three cases in the control group dropped off,and the falling-off cases in the two groups were counted as invalid cases.(2)After four weeks of treatment,the total effective rate of the trial group was 80.00%(24/30)and that of the control group was 53.33%(16/30),and the intergroup comparison(by chi-square test)showed that the therapeutic efficacy of the trial group was significantly superior to that of the control group(P＜0.05).(3)After treatment,liver function indicators such as alanine transaminase(ALT),aspartate transaminase(AST),total bilirubin(TBIL),and direct bilirubin(DBIL)in the two groups were significantly improved compared with those before treatment(P＜0.05),and the improvement of liver function indicators in the trial group was significantly superior to that in the control group(P＜0.05).(4)After treatment,the prothrombin time(PT)of patients in the two groups was significantly improved when compared with that before treatment(P＜0.05),and the improvement of PT in the trial group was significantly superior to that in the control group(P＜0.05).Conclusion The integrative Chinese and western medicine therapy with the utilization of Niujiao Dihuang Jiedu Decoction is effective in treating ACLF patients with toxic-heat-stasis stagnation type,which can significantly improve the liver function and coagulation function of the patients.The therapeutic efficacy of the integrative therapy is significantly superior to that of the western medicine comprehensive treatment alone,which has high clinical value.
