Effect of Shenqi Granules on the Prognosis of Patients Suffering from Heart Failure with Preserved Ejection Fraction of Qi Deficiency and Blood Stasis Type
10.13359/j.cnki.gzxbtcm.2024.12.010
- VernacularTitle:参七颗粒对气虚血瘀型射血分数保留心衰患者预后的影响
- Author:
Jiang-Hao LIU
1
;
Hua-Yun ZHAO
Author Information
1. 广州中医药大学第八临床医学院,广东佛山 528000
- Keywords:
Shenqi Granules;
qi deficiency and blood stasis type;
heart failure with preserved ejection fraction;
HFpEF;
cardiopulmonary exercise testing;
N-terminal pro-brain natriuretic peptide;
NT-proBNP
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(12):3154-3160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Shenqi Granules(composed of Ginseng Radix et Rhizoma Rubra and Notoginseng Radix et Rhizoma)on the prognosis of patients suffering from heart failure with preserved ejection fraction(HFpEF)of qi deficiency and blood stasis type.Methods A total of 130 patients with HFpEF of qi deficiency and blood stasis type were randomly divided into the observation group and the control group,with 65 patients in each group.The control group was treated with conventional western medicine,and the observation group was treated with Shenqi Granules on the basis of treatment for the control group.The course of treatment for the two groups covered six months.Before and after treatment,the changes of cardiopulmonary exercise testing(CPET)indicators,left ventricular ejection fraction(LVEF),traditional Chinese medicine(TCM)syndrome scores and serum N-terminal pro-brain natriuretic peptide(NT-proBNP)level in the two groups were observed.After treatment,the efficacy for TCM syndrome and clinical safety in the two groups were evaluated.Results(1)After six months of treatment,the total effective rate of the observation group was 89.23%(58/65),and that of the control group was 71.31%(47/65).The intergroup comparison(by chi-square test)showed that the efficacy for TCM syndrome in the observation group was significantly superior to that in the control group,and the difference was statistically significant(P＜0.05).(2)After treatment,CPET indicators such as the maximal oxygen uptake(VO2max),anaerobic threshold(AT),metabolic equivalents of task(METs),and slope value(the ratio of ventilation to carbon dioxide production,VE/VCO2)were increased in the two groups when compared with those before treatment(P＜0.05),and the increase of VO2max,AT,METs,and VE/VCO2 in the observation group was significantly superior to that in the control group.There were statistically significant differences in the post-treatment levels of CPET indicators and in the pre-and post-treatment difference value of CPET indicators between the two groups(P＜0.01).(3)After treatment,the LVEF values of the two groups were increased(P＜0.05)and the serum NT-proBNP levels were decreased when compared with those before treatment(P＜0.05),and the increase of the LVEF value and the decrease of the serum NT-proBNP level in the observation group were significantly superior to those in the control group.And statistically significant differences were shown in the post-treatment levels of cardiac function indicators and in the pre-and post-treatment difference value of cardiac function indicators between the two groups(P＜0.01).(4)After treatment,the TCM syndrome scores of the two groups of patients were decreased when compared with those before treatment(P＜0.05),and the decrease of TCM syndrome scores of the observation group was significantly superior to that of the control group.There were statistically significant differences in the post-treatment scores and in the pre-and post-treatment difference value of scores between the two groups(P＜0.01).(5)During the treatment,there were no obvious adverse reactions occurring in both groups,or no abnormal changes were shown in the safety indexes such as blood routine test,urine routine test,stool routine test,liver and kidney function examination of the patients.Conclusion Shenqi Granules can significantly improve the prognosis of HFpEF patients with qi deficiency and blood stasis type,and effectively decrease the serum NT-proBNP level.
