Clinical Observation of Xinma Granules Combined with Acupoint Application in the Treatment of Chronic Cough with Phlegm and Stasis Obstructing the Lung Type
10.13359/j.cnki.gzxbtcm.2024.12.009
- VernacularTitle:辛麻颗粒联合穴位贴敷治疗痰瘀阻肺型慢性咳嗽的疗效观察
- Author:
Xi-Zhuo LIAO
1
;
Hai-Fang ZHAO
;
Yun-Ying YANG
Author Information
1. 广州中医药大学第五临床医学院,广东广州 510405
- Keywords:
chronic cough;
phlegm and stasis obstructing the lung;
Xinma Granules;
Compound Methoxyphenamine Capsules;
acupoint application;
lung function;
quality of life;
clinical efficacy
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(12):3147-3153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of Xinma Granules(mainly composed of Asari Radix et Rhizoma,Belamcandae Rhizomas,Schisandrae Chinensis Fructus,honey-prepared Ephedrae Herba,Citri Reticulatae Pericarpium and Pinelliae Rhizoma Praeparatum)combined with acupoint application in the treatment of chronic cough with phlegm and stasis obstructing the lung type.Methods A retrospective study was conducted in 72 outpatients from the Department of Respiratory Medicine,Guangdong Second Traditional Chinese Medicine Hospital from April 2022 to April 2023,which suffered from chronic cough of phlegm and stasis obstructing the lung type.The patients were divided into the observation group and the control group according to the treatment method,with 36 patients in each group.The control group was treated with Compound Methoxyphenamine Capsules,and the observation group was treated with Xinma Granules combined with acupoint application on the basis of treatment for the control group.The treatment course for the two groups covered one week.Before and after the treatment,the changes of pulmonary function indicators of forced expiratory volume in one second(FEV1),traditional Chinese medicine(TCM)syndrome scores,and Leicester Cough Questionnaire(LCQ)scores for the quality of life in the two groups were observed.After treatment,the clinical efficacy and adverse reaction occurrence in the two groups of patients were evaluated.Results(1)After one week of treatment,the disease control rate and total effective rate in the observation group were 44.44%(16/36)and 97.22%(35/36),and those in the control group were 16.67%(6/36)and 94.44%(34/36),respectively;the intergroup comparison showed that the difference of the total effective rate(by chi-square test)in the two groups was not statistically significant(P＞0.05),but the disease control rate(by chi-square test)and the total efficacy(by rank sum test)of the observation group were significantly superior to those of the control group(P＜0.05).(2)After treatment,the lung function indicators of FEV1 in the two groups were higher when compared with those before treatment(P＜0.05),and the increase of FEV1 in the observation group tended to be superior to that in the control group,without statistically significant difference(P＞0.05).(3)After treatment,the LCQ scores for the quality of life in the two groups were increased compared with those before treatment(P＜0.05),and the increase of LCQ score in the observation group was significantly superior to that in the control group(P＜0.05).(4)After treatment,the TCM syndrome scores in the two groups were significantly lower when compared with those before treatment(P＜0.05),and the decrease of LCQ score in the observation group was significantly superior to that in the control group(P＜0.05).(5)The incidence of adverse reactions in the observation group and the control group was all 5.56%(2/36),and the intergroup comparison showed that the difference was not statistically significant(P＞0.05).Conclusion Xinma Granules combined with acupoint application is effective and safe in the treatment of chronic cough with phlegm and stasis obstructing the lung type by enhancing the clinical efficacy and significantly improving the quality of life of patients.
