Correlation Between Lipoprotein(a)Combined with Maximum Carotid Intima-Media Thickness and Coronary Heart Disease with Blood Stasis Syndrome:A Retrospective Study
10.13359/j.cnki.gzxbtcm.2024.12.002
- VernacularTitle:脂蛋白(a)联合最大颈动脉内膜中层厚度与冠心病血瘀证相关性的回顾性研究
- Author:
Ke-Ting YANG
1
;
Shu-Jie HAN
;
Chuang-Chang WANG
;
Sheng-Ming LUO
;
Xia WANG
Author Information
1. 广州中医药大学第二临床医学院,广东广州 510405
- Keywords:
coronary heart disease;
blood stasis syndrome;
lipoprotein(a);
carotid ultrasonography;
carotid intima-media thickness;
predictive value
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(12):3104-3109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between lipoprotein(a)[Lp(a)]combined with maximum carotid intima-media thickness(CIMT)and coronary heart disease with blood stasis syndrome,and to assess its predictive value.Methods A total of 207 patients with coronary heart disease who were hospitalized in the Cardiovascular Department of Guangdong Provincial Hospital of Chinese Medicine(Dade Road Hospital)from January 2023 to January 2024 were selected.According to the Diagnostic Criteria for Blood Stasis Syndrome of Coronary Heart Disease,the patients were divided into the blood stasis syndrome group(110 cases)and the non-blood stasis syndrome group(97 cases).Before coronary angiography,the clinical data such as Lp(a),CIMT and glycosylated hemoglobin(HbA1c)of the patients were collected.Multivariate Logistic regression analysis was conducted to explore the independent risk factors of blood stasis syndrome in the patients with coronary heart disease,and the receiver operating characteristic(ROC)curve was drawn for the analysis of the predictive efficacy of the indicators,independently and jointly.Results(1)The results of univariate analysis showed that the percentages of the patients having drinking history,hypertension history,and diabetes in the blood stasis syndrome group and the levels of HbA1c,Lp(a),and maximum CIMT were higher when compared with those in the non-blood stasis syndrome group(P＜0.05 or P＜0.01).(2)The results of multivariate Logistic regression analysis showed that Lp(a)[OR=1.004,95%CI(1.002-1.005)],increased level of maximum CIMT[OR=10.999,95%CI(1.897-63.784)],and history of hypertension[OR=2.354,95%CI(1.141-4.856)]were independent risk factors for blood stasis syndrome in the patients with coronary heart disease(P＜0.05 or P＜0.01).(3)The results of ROC curve analysis showed that the area under the curve(AUC)of ROC for the prediction of blood stasis syndrome in the patients with coronary heart disease by Lp(a),maximum CIMT,Lp(a)combined with maximum CIMT model,Lp(a)+maximum CIMT combined with hypertension model were 0.749,0.650,0.773,and 0.787,respectively(P＜0.001),and the sensitivity of the two combined diagnostic models was 0.655 and 0.736,and their specificity was 0.804 and 0.742,respectively.Conclusion The combined detection of Lp(a)and maximum CIMT can enhance the predictive efficacy of blood stasis syndrome in the patients with coronary heart disease,and will provide evidence for the clinical identification of blood stasis syndrome in the patients with coronary heart disease.
