Research progress in the clinical application and mechanisms of Chinese materia medica in treating chronic atrophic gastritis of spleen-stomach damp-heat syndrome
10.3760/cma.j.cn115398-20250407-00091
- VernacularTitle:中药治疗脾胃湿热型慢性萎缩性胃炎临床应用及作用机制研究进展
- Author:
Lining SU
1
;
Junhong LIU
;
Dan WANG
;
Jinxue ZHANG
;
Hongmei LI
;
Bingrui XU
;
Jiale CHEN
;
Yudie HE
Author Information
1. 甘肃中医药大学中西医结合学院2023级硕士研究生，兰州 730030
- Keywords:
Gastritis, atrophic;
Spleen-stomach damp-heat syndrome;
Chinese materia medica;
Clinical application;
Mechanism;
Review
- From:
International Journal of Traditional Chinese Medicine
2025;47(12):1792-1797
- CountryChina
- Language:Chinese
-
Abstract:
Spleen-stomach damp-heat syndrome is currently the most prevalent TCM pattern in patients with chronic atrophic gastritis (CAG), with internal damp-heat accumulation regarded as a key factor contributing to its prolonged and refractory course. This syndrome represents a critical stage in the progressive pathogenesis of CAG, characterized by a deepening pathological evolution. Modern TCM practitioners generally agree that its core pathogenesis lies in "deficiency in root and excess in superficiality, with internal damp-heat retention", and emphasize a treatment strategy that combines eliminating pathogenic factors and reinforcing the body's healthy qi through dynamic syndrome differentiation. Chinese materia medica used in treating CAG with spleen-stomach damp-heat syndrome can effectively relieve clinical symptoms, improve the internal damp-heat environment, mitigate gastric mucosal atrophy and intestinal metaplasia, and delay the inflammation-to-cancer transformation. Its mechanisms may involve eradication of Helicobacter pylori, repair of gastric mucosal injury, regulation of immune inflammatory response and other aspects, which has the advantages of multi-channel and multi-target.
