Research progress in anti-tumor mechanism of Hedyotidis Herba regulating central carbon metabolism pathway
10.3760/cma.j.cn115398-20250409-00117
- VernacularTitle:白花蛇舌草调控中心碳代谢通路抗肿瘤机制研究进展
- Author:
Yiwen ZHANG
1
;
Yanjie WANG
;
Huijun ZHANG
;
Xuebing JIN
;
Zhimin CHEN
Author Information
1. 黑龙江中医药大学2023级硕士研究生，哈尔滨 150040
- Keywords:
Neoplasms;
Hedyotidis Herba;
Central carbon metabolism;
Signaling pathways;
Review
- From:
International Journal of Traditional Chinese Medicine
2025;47(12):1786-1791
- CountryChina
- Language:Chinese
-
Abstract:
Tumor's occurrence and development are closely related to metabolic abnormalities. Central Carbon Metabolism (CCM) is the core network of biological metabolism, and its abnormal activation drives tumor cell proliferation, invasion, and immune escape. Hedyotidis Herba is a classic anti-tumor conventional Chinese materia medica. Its active components interfere with the core links of CCM (glycolysis, tricarboxylic acid cycle and pentose phosphate pathway) by targeting key signaling pathways such as PI3K/Akt, AMPK, P53, Wnt/β-catenin, MAPK, Nrf2 and TGF-β, so as to inhibit the energy metabolism of tumor cells, regulate the acidification state of microenvironment, block the production of metabolic precursors, and curb tumor cell metastasis and immune escape.
