Research progress in the anti-tumor mechanism of Sanghuangporus
10.3760/cma.j.cn115398-20250509-00081
- VernacularTitle:桑黄抗肿瘤作用机制研究进展
- Author:
Chen CHEN
1
;
Ji CHEN
;
Haixia SHI
;
Qijun ZHANG
Author Information
1. 上海市浦东新区肺科医院中医科，上海 201209
- Keywords:
Medicinal fungi;
Sanghuangporus sanghuang;
Sanghuangpours vaninii;
Sanghuangporus baumii;
Chemical composition;
Neoplasms;
Mechanism;
Review
- From:
International Journal of Traditional Chinese Medicine
2025;47(12):1780-1785
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents such as polysaccharides, flavonoids and polyphenols in Sanghuangporus have anti-tumor, anti-inflammatory, anti-oxidation and immune regulation effects. Sanghuangporus and its chemical constituents have shown anti-tumor activity against lung cancer, gastric cancer, liver cancer, colorectal cancer, breast cancer, melanoma, glioma and other malignant tumor cells. The mechanism mainly includes blocking cell cycle, inducing apoptosis and autophagy, inhibiting cell metastasis, immune regulation, etc., and can cooperate with radiotherapy and chemotherapy, targeted therapy, by inducing tumor cell apoptosis, blocking cell cycle, inhibiting inflammatory response, alleviating oxidative stress, etc., in order to play a role in reducing toxicity and increasing efficiency. In the future, small molecules and monomers with anti-tumor activity in Sanghuangporus can be screened. The varieties, producing areas and cultivation methods of Sanghuang would be standardized, and the bioavailability is improved by the development of new dosage forms. Through modern molecular biology and multi-omics techniques, the specific mechanism and target of its anti-tumor effect would be comprehensively explored. Pharmacodynamic toxicology research and large-scale clinical trials would be combined to verify its safety, so as to provide more evidence for its clinical application.
