Clinical study on modified Xiaoxuming Decoction combined with conventional Western medicine therapy for the treatment of wind phlegm obstructing collaterals syndrome in the recovery period of ischemic stroke
10.3760/cma.j.cn115398-20241114-00179
- VernacularTitle:续命汤加减结合西医常规疗法治疗缺血性卒中恢复期风痰阻络证的临床研究
- Author:
Weiyu XU
1
;
Furong LYU
;
Xiaoyan WANG
;
Yongyi JI
;
Wenxin DANG
;
Meng LUO
;
Zhengzheng WEN
;
Yihan LIU
;
Rui ZUO
Author Information
1. 陕西中医药大学西安附属医院（西安市中医医院）脑病科，西安 710021
- Keywords:
Ischemic stroke;
Xiao Xu Ming Tang;
Recovery period;
Repeated measures analysis of variance
- From:
International Journal of Traditional Chinese Medicine
2025;47(10):1365-1369
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical efficacy of Xiaoxuming Decoction combined with conventional Western medicine therapy in the treatment of patients with ischemic stroke in the recovery period.Methods:A randomized controlled clinical study was conducted. A total of the 118 patients with wind phlegm obstructing collaterlas syndrome during the recovery period of ischemic stroke in our hospital from September 2023 to July 2024 were selected as the observation subjects. They were divided into two groups using a random number table method, with 59 patients in each group. The control group was treated with conventional Western medicine therapy, while the TCM group was treated with modified Xiaoxuming Decoction on the basis of the control group. Both groups were treated for 2 months and followed up for 1 month. TCM syndrome scoring was performed before and after treatment, Barthel Index was used to evaluate daily living ability, and carotid artery ultrasound detector was used to evaluate the stability of carotid vascular plaques. Inter group comparisons were performed using t test, χ2 test, or repeated measures analysis of variance (RM-ANOVA). Results:RM-ANOVA showed that the time effect and inter group effect of TCM syndrome integration in the TCM group were significantly different from those in the control group ( Ftime=55.56, Ptime<0.001); Fbetween=18.94, Pbetween<0.001); there was no statistical significance in the interaction effect compared to the control group ( Finteraction=0.24, Pinteraction=0.866); the time effect, inter group effect, and interaction effect of Barthel Index in the TCM group were significantly different from those in the control group ( Ftime=44.57, Ptime<0.001); Fbetween=18.94, Pbetween<0.001; Finteraction=7.45, Pinteraction<0.001). The number of patients with unstable plaques in the TCM group after 3 months of treatment was lower than that in the control group ( χ2=4.52, P=0.033). Conclusion:The combination of modified Xiaoxuming Decoction and conventional Western medicine therapy can effectively improve the clinical symptoms and daily living ability of patients in the recovery period of ischemic stroke, improve the stability of cervical vascular plaques, and the clinical efficacy becomes more significant over time.
