Exploration of the effect and design of placebo manipulation in clinical trials of manipulation
10.3760/cma.j.cn115398-20241123-00288
- VernacularTitle:手法临床试验中安慰剂手法的效果与设计探究
- Author:
Changhe YU
1
;
Hualong LU
;
Zhifeng LIU
;
Hui SHAO
;
Baolin JIA
;
Hao WANG
;
Xiyou WANG
;
Yanan SUN
Author Information
1. 北京中医药大学东直门医院推拿疼痛科，北京 100700
- Keywords:
Pain;
Manipulation therapy;
Placebo effect;
Blinding;
Patient expectations
- From:
International Journal of Traditional Chinese Medicine
2025;47(10):1353-1358
- CountryChina
- Language:Chinese
-
Abstract:
This article summarized the current status and challenges of manipulation therapy for musculoskeletal pain and its placebo effect in clinical trials, analyzing the impact of the placebo effect on the evaluation of therapeutic efficacy. The efficacy of different manual manipulation techniques remains uncertain, and the degree of blinding and patient expectations play a crucial role in efficacy assessment. The article suggested improving trial design through standardized placebo intervention design, comprehensive investigation of patient expectations and psychological states, rigorous training of practitioners, and optimized diagnostic and treatment scenarios and doctor-patient relationship, to ensure consistency between intervention and placebo groups. Specific measures include the application of the DITTO (Deconstruct, Identify, Take out, Think, Optimize) framework, the use of standardized questionnaire tools, and multi-center, large-sample randomized controlled trials to enhance the external validity and statistical power of research results, thereby providing more scientifically reliable evidence for clinical practice.
