Exploration on the mechanism of lung cancer treatment from the perspective of phlegm pathogen theory based on inflammatory-metabolic-immune microenvironment
10.3760/cma.j.cn115398-20250423-00329
- VernacularTitle:基于肿瘤炎性-代谢-免疫微环境探讨肺癌从痰邪论治的作用机制
- Author:
Yuanjiafan CHEN
1
;
Yaxing LI
;
Shaobo HU
;
Hongzhen YIN
;
Chongyang QU
;
Shuzhen DUAN
;
Yinghua LI
;
Jie LI
Author Information
1. 内蒙古医科大学中医临床医学院2024级硕士研究生，呼和浩特 010010
- Keywords:
Lung neoplasms;
Phlegm pathogenr;
Inflammatory microenvironment;
Metabolic microenvironment;
Immune microenvironment
- From:
International Journal of Traditional Chinese Medicine
2025;47(10):1341-1346
- CountryChina
- Language:Chinese
-
Abstract:
The tumor microenvironment (TME) is the cellular milieu in which tumor cells thrive, comprising interacting cells and associated factors that form a complex network of interactions, directly or indirectly influencing the initiation, progression, and metastasis of lung cancer. Through TCM pattern identification, it has been observed thatphlegm-pathogen is closely associated with disorder in the inflammatory-metabolic-immune microenvironments of lung cancer. This involves three key pathological mechanisms: "phlegm-stasis complicated by toxin, qi deficiency with exuberant phlegm, and phlegm-pathogen impairing healthy qi". Molecular mechanism studies have revealed that phlegm-resolving agents can extensively modulate multiple targets or pathways, thereby remodeling the inflammatory-metabolic-immune microenvironments of lung cancer. Consequently, a comprehensive therapeutic strategy integrating "resolving phlegm, dispelling stasis, and detoxifying; supplementing qi, warming yang, and resolving phlegm; and reinforcing healthy qi, tonifying the lung, and eliminating phlegm" is essential to reshape the lung cancer TME and enhance antitumor efficacy.
