Research progress in the mechanism of Chinese materia medica in the treatment of viral pneumonia based on signaling pathway
10.3760/cma.j.cn115398-20250102-00028
- VernacularTitle:基于信号通路的中药治疗病毒性肺炎机制研究进展
- Author:
Jiaqi SHANG
1
;
Xin PENG
;
Zheyu LUAN
;
Yunfan WANG
;
Yihao ZHANG
;
Jihong FENG
Author Information
1. 天津中医药大学2022级硕士研究生，天津 300250
- Keywords:
Pneumonia, viral;
NF-κB signaling pathway;
MAPK signaling pathway;
JAK/STAT signaling pathway;
PI3K/Akt signaling pathway;
Review
- From:
International Journal of Traditional Chinese Medicine
2025;47(9):1332-1336
- CountryChina
- Language:Chinese
-
Abstract:
The research on the mechanism of Chinese materia medica in the treatment of viral pneumonia (VP) is mainly based on the monomer components of Chinese materia medica and TCM compounds. Among them, the monomer components are mainly polyphenols, flavonoids and anthraquinones, which have anti-inflammatory, antiviral, immunomodulatory and antioxidant pharmacological effects. The efficacy of TCM compounds is mainly based on clearing heat, and it has the functions of removing phlegm, removing blood stasis, removing dampness, moistening lung and so on. The intervention of Chinese materia medica in VP mainly involves NF-κB, MAPK, JAK/STAT, PI3K/Akt and other signaling pathways. The mechanism includes regulating oxidative stress, apoptosis, regulating immune function, inhibiting inflammatory response, etc., which can reduce the pathological damage of inflammatory cell infiltration and edema in lung tissue, and achieve the protective effect on lung tissue. The current research models exhibit unclear patterns of syndrome differentiation, and the mechanisms of Chinese materia medica involving multiple targets and pathways are poorly understood. Future research should integrate disease-syndrome combination models to further explore the mechanisms by which TCM regulates multiple targets and pathways, thereby providing insights and methodologies for the treatment of viral pneumonia with Chinese materia medica.
