Research progress in mechanism of Chinese materia medica for the prevention and treatment of diminished ovarian reserve based on signaling pathways
10.3760/cma.j.cn115398-20240924-00266
- VernacularTitle:基于信号通路的中药防治卵巢储备功能减退机制研究进展
- Author:
Xinwan MENG
1
;
Weiyi LI
;
Xinyu LIU
;
Yongmei HAN
Author Information
1. 河南中医药大学第一临床医学院2022级硕士研究生，郑州 450046
- Keywords:
Ovarian reserve;
Signal pathway;
Traditional Chinese Medicine;
Research progress;
Review
- From:
International Journal of Traditional Chinese Medicine
2025;47(8):1178-1183
- CountryChina
- Language:Chinese
-
Abstract:
Chinese materia medica mainly prevents and treats diminished ovarian reserve by regulating PI3K/Akt, PI3K/Akt/mTOR, PI3K/Akt/FoxO3, PTEN/PI3K/Akt, TGF-β1/Smads, Nrf2/HO-1, AMPK and other signaling pathways. It also involves Hippo, Wnt / β-catenin, Notch and other signaling pathways, which can improve the ovarian environment, promote ovarian function repair, inhibit ovarian granulosa cell apoptosis, promote oocyte growth, regulate hormone levels, and play anti-inflammatory, anti-oxidation and anti-fibrosis roles.
