Research progress in signaling pathways related to TCM treatment for chronic refractory wounds
10.3760/cma.j.cn115398-20240919-00213
- VernacularTitle:中药治疗慢性难愈性创面相关信号通路研究进展
- Author:
Lihuan YANG
1
;
Lianheng XIA
;
Yufei XU
;
Linggen LI
;
Jie GAO
Author Information
1. 黑龙江中医药大学2023级博士研究生，哈尔滨 150040
- Keywords:
Chronic refractory wounds;
Signaling pathway;
Research progress;
Wound healing;
Review
- From:
International Journal of Traditional Chinese Medicine
2025;47(7):1022-1027
- CountryChina
- Language:Chinese
-
Abstract:
PI3K/Akt, Wnt/β-catenin, TGF-β, Nrf2 and Notch signaling pathways are mainly involved in the TCM treatment of chronic refractory wounds (CRW). Chinese materia medica monomers and compound preparations can inhibit protein kinases related to signaling pathways in wound tissue and promote wound healing; reduce the expression of inflammatory factors and inhibit the occurrence of inflammatory response; promote the proliferation and differentiation of growth factors and epidermal stem cells, accelerate the regeneration of granulation tissue, and play a role in repairing wound regeneration.
