Study on the medication law of TCM compound patents for primary dilated cardiomyopathy based on data mining
10.3760/cma.j.cn115398-20240924-00272
- VernacularTitle:基于数据挖掘的中药复方专利治疗原发性扩张型心肌病组方用药规律研究
- Author:
Jinyuan ZHANG
1
;
Wei LIU
;
Hongxu LIU
;
Xiaolei LAI
;
Tong TONG
;
Yanjie LIAN
Author Information
1. 首都医科大学附属北京中医医院心血管科，北京 100010
- Keywords:
Cardiomyopathy, dilated;
Data mining;
TCM compounds;
Patent;
Medication law
- From:
International Journal of Traditional Chinese Medicine
2025;47(7):992-998
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the medication law of TCM compound patents for treating primary dilated cardiomyopathy (DCM) based on data mining.Methods:TCM compound patents for the treatment of DCM were retrieved from State Intellectual Property Office of China-Chinese Patent Publication Notice webpage from the establishment of the database to November 18, 2024. After extracting information, statistics were conducted on patent publication time, indications, drug frequency, etc. The association rules of drugs were analyzed using SPSS Modeler 18.0 software based on the Apriori algorithm, and the core drug co-occurrence relationship was visualized using Cytascape 3.9.1 software. SPSS 27.0 software was used to cluster the high-frequency drugs and core co-occurrence drugs. The MCODE plug-in of Cytascape 3.9.1 software was used for graphic clustering analysis.Results:A total of 52 patents were included in this study, with high-frequency syndromes of qi deficiency and blood stasis (16 times), qi and yin deficiency (13 times), blood stasis and water stagnation syndrome (5 times), etc. A total of 236 kinds of Chinese materia medica were involved, with high-frequency herbal medicines such as Astmgali Radix (34 times), Salvia Miltiorrhiza (24 times), Poria (22 times), Ophiopogonis Radix (19 times), etc.; common pairs were Poria → Astmgali Radix (rule support 34.62%, confidence 81.82%), Atractylodes Macrocephala → Poria (rule support 25.0%, confidence 100%), etc.; common medicinal combinations were Atractylodes Macrocephala - Astmgali Radix → Poria (rule support 21.15%, confidence 100%), Astmgali Radix-Schisandrae Chinensis Fructus → Ophiopogonis Radix (rule support 21.15%, confidence 91.67%), etc.; new prescriptions included "Poria, Atractylodes Macrocephala, Ginseng Radix et Rhizoma, Cmnamomi Mmulus, Descurainiae Semen, Aconiti Lateralis Radix Praeparaka, Polyporus", etc.; potential Chinese medicine combinations included "Aconitum Bullatifolium-Eupolyphaga Steleophaga-Myrrh-Os Costaziae-Os Draconis-Olibanum-Moschus-Pyritum", etc.Conclusion:TCM compound patents for treating DCM mainly include qi deficiency and blood stasis, qi-yin deficiency , blood stasis and water stagnation, etc. The basic treatment method is to tonify qi and nourish yin, invigorate blood circulation and eliminate blood stasis, promote water circulation and reduce swelling, and cooperate with the method of softening and dispersing knots.
