Research progress in the mechanism of acupuncture in the treatment of chronic pain combined with depression
10.3760/cma.j.cn115398-20240707-00076
- VernacularTitle:针刺治疗慢性疼痛合并抑郁作用机制研究进展
- Author:
Tian WANG
1
;
Xi ZHANG
;
Pu YANG
;
Xin LI
;
Wenjing HUANG
;
Guangmei ZHENG
;
Xinyu HUANG
;
Songlin LEI
;
Shengyong SU
Author Information
1. 广西中医药大学2023级博士研究生，南宁 530200
- Keywords:
Acupuncture;
Chronic pain with depression;
Mechanism;
Review
- From:
International Journal of Traditional Chinese Medicine
2025;47(6):877-880,F4
- CountryChina
- Language:Chinese
-
Abstract:
Acupuncture treatment of chronic pain combined with depression (CPDC) is the result of a multi-target, multi-pathway approach. Acupuncture can treat CPDC by inhibiting the activation of glial cells, regulating the release of inflammatory mediators, regulating the expressions of neurotransmitters, changing the plasticity of neural synapses, regulating related epigenetic effects, regulating the microbiota-brain-gut axis, inhibiting nerve cell apoptosis, and antagonizing oxidative stress. The mechanism of its effect mainly involves anti-inflammatory related signaling pathways, regulation of neural synapse-related signaling pathways, and exerts its therapeutic effect through hippocampus, cerebral cortex, and amygdala.
