Modern research progress of damp-heat confirmed constitution
10.3760/cma.j.cn115398-20240528-00263
- VernacularTitle:湿热证实质的现代研究进展
- Author:
Ruining LU
1
;
Yanhong LIU
;
Kaifeng LI
;
Zhongcheng YANG
;
Guiju ZHANG
Author Information
1. 山东中医药大学附属医院儿科，济南 250011
- Keywords:
Dampness heat;
Syndrome complex;
Aquaporin;
Intestinal bacterium;
Omics technology;
Review
- From:
International Journal of Traditional Chinese Medicine
2025;47(5):715-719
- CountryChina
- Language:Chinese
-
Abstract:
The research of damp-heat syndrome in modern TCM mainly focuses on inflammatory response, water metabolism, lipid metabolism, hemorheology, intestinal flora and so on. Modern omics techniques such as metabolomics and genomics provide a new perspective for the exploration of the micro-mechanism of damp-heat syndrome. The study found that the abnormal expression of aquaporin is closely related to the formation of "dampness" in damp-heat syndrome, and the release of inflammatory factors reflects the pathological characteristics of "heat". Damp-heat syndrome is often accompanied by dyslipidemia, hemorheological changes and intestinal flora imbalance, showing characteristic changes in urine, blood and saliva metabolomics, and there are differences in gene expression between damp-heat constitution and gentleness constitution. In the future, the pertinence and systematicness of research should be strengthened, the relationship between indicators should be deeply explored, build a biomarker system should be built, the immune-metabolic regulation mechanism should be explored, the multi-target mechanism of heat-clearing and dampness-removing Chinese materia medica should be clarified to further improve the damp-heat syndrome system, and provide theoretical support for clinical treatment.
