Clinical study on transmural follicle-activating herbal medicine combined with electroacupuncture in luteinized unruptured follicle syndrome
10.3760/cma.j.cn115398-20240703-00034
- VernacularTitle:透壁促氲中药联合电针治疗未破裂卵泡黄素化综合征的临床研究
- Author:
Jie BAI
1
;
Yan ZHAO
;
Ruihong YOU
Author Information
1. 石家庄市中医院妇科，石家庄 050011
- Keywords:
Infertility, female;
Unruptured follicle luteinization syndrome;
Transmural dense herbs;
Electroacupuncture
- From:
International Journal of Traditional Chinese Medicine
2025;47(5):607-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical efficacy of transmural follicle-activating herbal medicine combined with electroacupuncture in luteinized unruptured follicle syndrome (LUFS).Methods:A randomized controlled trial (RCT) was conducted. Totally 90 LUFS patients in our hospital from November 2018 to January 2021 were selected as the observation subjects, and were divided into three groups using a random number table method, with 30 patients in each group. The Chinese materia medica group was treated with transmural follicle-activating herbal medicine, the acupuncture-medicine combination group was treated with transmural follicle-activating herbal medicine + electroacupuncture, and the Western medicine group was treated with injection of chorionic gonadotropin (hCG). The ovarian blood flow pulsatility index (PI) and resistance index (RI) of patients before and after treatment were observed. Chemiluminescence was used to detect the levels of estradiol (E 2), progesterone (P), and LH. Ovulation, pregnancy, and LUFS recurrence and adverse reactions after treatment were observed, and clinical efficacy was evaluated. Results:The total effective rate of the acupuncture-medicine combination group was 86.67% (26/30), the Chinese materia medica group was 63.33% (19/30), and the Western medicine group was 60.00% (18/30). There was a statistical significance among the three groups ( χ2=6.03, P=0.049). After treatment, there was a statistical significance in ovarian blood flow PI (1.57 ± 0.51 vs. 1.85 ± 0.56 vs. 1.90 ± 0.61, F=2.03), RI (0.48 ± 0.14 vs. 0.57 ± 0.18 vs. 0.62 ± 0.20, F=2.16) ( P<0.05); the serum E 2 [(322.60 ± 62.31) ng/L vs. (289.58 ± 55.45) ng/L vs. (291.17 ± 63.69) ng/L, F=2.26], P [(16.36 ± 4.14) μg/L vs. (13.45 ± 3.68) μg/L vs. (13.71 ± 3.50) μg/L, F=3.58], LH [(27.19 ± 5.04) IU/ml vs. (21.52 ± 4.66) IU/ml vs. (22.58 ± 4.80) IU/ml, F=3.68] levels were compared, and the differences were statistically significant ( P<0.05, P<0.01). The ovulation rate [93.33% (28/30) vs. 66.67% (20/30) vs. 63.33% (19/30), χ2=13.01] and pregnancy rate [53.33% (16/30) vs. 30.00% (9/30) vs. 26.67% (8/30), χ2=6.11], the recurrence rate of LUFS [19.23% (5/26) vs. 47.37% (9/19) vs. 55.56% (10/18), χ2=6.94] in the needle-medicine combination group, the Chinese materia medica group and the Western medicine group after treatment were significantly different ( P<0.05). During the treatment period, there was no statistical significance in the occurrence of adverse reactions among the three groups ( χ2=2.02, P=0.364). Conclusion:The transmural follicle-activating herbal medicine combined with electroacupuncture demonstrates superior efficacy in LUFS management by improving ovarian perfusion and endocrine function, with higher ovulation/pregnancy rates and lower recurrence.
