Study on the TCM compatibility law in the treatment of diabetic nephropathy based on LDA topic model and association rules
10.3760/cma.j.cn115398-20240207-00057
- VernacularTitle:基于LDA主题模型和关联规则的中药治疗糖尿病肾病组方配伍规律研究
- Author:
Min WU
1
;
Lufeng ZHENG
;
Hui XU
;
Ping LIU
;
Xiaorong CHEN
;
Tiancai WEN
Author Information
1. 中国中医科学院中医药数据中心2022级硕士研究生，北京 100700
- Keywords:
Diabetic nephropathies;
Traditional Chinese Medicine;
LDA topic model;
Association rule;
Ancient and modern medical record cloud platform
- From:
International Journal of Traditional Chinese Medicine
2025;47(2):250-255
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the medication thinking and compatibility rules of TCM for the treatment of diabetic nephropathy (DN).Methods:Relevant journal literature of TCM for the treatment of DN was retrieved from CNKI, Wanfang Data, VIP, and CBM from January 1, 2000 to December 31, 2023, and a database was established through Excel 2016. Python 3.10 and the ancient and modern medical record cloud platform 2.3.5 were used to conduct Latent Dirichlet Allocation (LDA) topic modeling and association rule analysis to explore the thinking and compatibility rules of TCM prescriptions in the literature.Results:A total of 474 articles were included in the study, including 474 prescriptions, involving 260 kinds of Chinese materia medica, of which 40 kinds of Chinese materia medica with a frequency of ≥ 30, mainly Astragali Radix, Salviae Miltiorrhizae Radix et Rhizoma, Dioscoreae Rhizoma, Poria, and Corni Fructus, etc. The LDA topic model identified three groups of prescriptions, including four classic prescriptions: Liuwei Dihuang Pills, Taohong Siwu Decoction, Erzhi Pills, and Wuling Powder. The commonly used drug combinations extracted by association rules were: Rhizoma Alismatis - Poria, Cortex Moutan Radicis-Fructus Corni and Cortex Moutan Radicis - Rhizoma Dioscoreae.Conclusions:The main therapeutic principle of TCM in treating DN is to nourish the yin and tonify the kidney, supplemented by drugs that promoting blood circulation for removing blood stasis as well as promoting urination and draining dampness. In clinical application, modern doctors tend to use classic prescriptions such as Liuwei Dihuang Pills, Erzhi Pills, Taohong Siwu Decoction, and Wuling Powder as the basis, and modify them according to the specific conditions of patients. The LDA topic model can extract valuable prescription information from a large number of modern TCM literature, providing new perspectives and ideas for the study of clinical medication rules in TCM.
